A Detailed Bromination Study of 7-Hydroxy-4-Methyl Benzopyran-2-One Under Classical Method and Microwave Irradiation

Authors

  • Vijay D. Gangan  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Ajaykumar C. Singh  Department of Chemistry, R. D. National College, Bandra (West) Mumbai, Maharashtra, India
  • Ruchira Joshi  Department of Chemistry, R. D. National College, Bandra (West) Mumbai, Maharashtra, India
  • Amod V. Tamhankar  COO, N. S. Chemicals, 601, Devavrata, sector 17, Vashi Navi Mumbai Maharashtra, India
  • Kalpana J. Bhatwadekar  Technical Director, Sirmaxo Chemicals Private Limited, Plot No.:, E, 35, Palghar, Tarapur Road, Tarapur M.I.D.C., Boisar, Maharashtra, India
  • Shyamlal T. Yadav  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Suyog S. Daye  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Dattatraya A. Dute  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Sakharam K. Godage  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Manoj Yewale  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Gaurav Pimple  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India
  • Arjun L. Ghorpade  Department of Chemistry, Loba Chemie Pvt. Ltd.,. Plot No. D-22, M.I.D.C.. Tarapur, Boisar Palghar, Maharashtra, India

DOI:

https://doi.org//10.32628/IJSRST1196231

Keywords:

Substituted Benzopyran, Classical Method, Microwave Irradiation, Protic and Aprotic Solvents, Allylic and Vinylic Bromination, 1H NMR, TOF MS ES and Elemental Analysis.

Abstract

7-Hydroxy-4-methyl benzopyran-2-one, Benzopyran a class of coumarin derivative, has been subjected for bromination under classical method, microwave irradiation and solvent-free protocol for allylic and vinylic bromination using liquid Br2, organic bromides, NBS, HBr-H2O2 and DDH as brominating agent under different protic and aprotic solvents. The efficacy of the bromination of benzopyran under classical method and microwave irradiation has been established. The effects of the bromination and location of the substituents on the outcome of the reaction have been rationalized by using 1H NMR and IR spectrum. Few of them showing promising antibacterial activity.

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International Journal of Scientific Research in Science and Technology

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Published

2019-04-30

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Volume 6, Issue 2, March-April-2019

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Research Articles

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[1]
Vijay D. Gangan, Ajaykumar C. Singh, Ruchira Joshi, Amod V. Tamhankar, Kalpana J. Bhatwadekar, Shyamlal T. Yadav, Suyog S. Daye, Dattatraya A. Dute, Sakharam K. Godage, Manoj Yewale, Gaurav Pimple, Arjun L. Ghorpade, " A Detailed Bromination Study of 7-Hydroxy-4-Methyl Benzopyran-2-One Under Classical Method and Microwave Irradiation, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 2, pp.205-213, March-April-2019. Available at doi : https://doi.org/10.32628/IJSRST1196231