Design and Synthesis of Novel Molecular Scaffolds of Bicaultamide Derivatives for the Treatment of Prostate Cell Cancer

Authors

  • Subrahmanyam Lanka  Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, India
  • Vaikuntarao Lakinani  Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, India
  • Sagar Rao Kanaparthi  Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, India
  • Siva Rama Rao Kakani  North East Frontier Technical University, Arunachal Pradesh, India

Keywords:

Bicaultamide, Prostate Cell Cancer, IC50, HEK293, Prostate cancer, CRPC

Abstract

Prostate cancer is a major cause of male death worldwide and the identification of new efficient treatments is constantly needed. Different non-steroidal androgen receptor antagonists are approved also in the case of castration-resistant cancer forms. Using a rational approach and molecular modelling studies to modify the structure of antiandrogen drug bicalutamide, a new series of phenylsulfonyl-benzamide derivatives was designed and synthesised. Their antiproliferative activities were evaluated in four different human prostate cancer cell lines and several new compounds showed significantly improved IC50 values in the low μM range. The cytotoxicity profile was also evaluated for the novel structures in the HEK293 cell line.

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International Journal of Scientific Research in Science and Technology

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Published

2019-04-30

Issue

Volume 6, Issue 2, March-April-2019

Section

Research Articles

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Copyright (c) IJSRST

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Subrahmanyam Lanka, Vaikuntarao Lakinani, Sagar Rao Kanaparthi, Siva Rama Rao Kakani, " Design and Synthesis of Novel Molecular Scaffolds of Bicaultamide Derivatives for the Treatment of Prostate Cell Cancer, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 6, Issue 2, pp.449-457, March-April-2019.