Formulation and Evaluation of Fast Dissolving Tabletes of Candesartan using Natural Excipients for the Treatment of Hypertension

Authors

  • Vaibhav N. Nagre  Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa Dist, Sangli, Maharashtra, India
  • Omprasad S. Niyakal  Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa Dist, Sangli, Maharashtra, India
  • Archana R. Dhole  Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa Dist, Sangli, Maharashtra, India
  • C.S. Magdum  Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa Dist, Sangli, Maharashtra, India

Keywords:

Sodium Starch Glycolate, Plantago ovata, Superdisintragate, Candisartan

Abstract

Candisartan is used commonly for the treatment of hypertantion. Candesartan shows, has a long duration of action. It has half-life of 9 hrs where asT max is 3-4 hr so rapidly achieve desired plasma concentration and stands for long time, so once daily dose is enough for onset of clinical effect , which is also convenient to the patient. Pharmaceutical products designed for oral delivery and currently available on the prescription and over-the-counter markets are mostly the immediate release type, which are designed for immediate release of drug for rapid absorption. Provides convenience to whom that has trouble in swallowing tablets. The objective of the present study was to prepare the mouth dissolving tablet of candisartan using different superdisintegrants. .The tablets were evaluated for hardness, friability, weight variation, wetting time, thickness, water absorption ratio, disintegrating time, uniformity of content and in-vitro drug release.

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International Journal of Scientific Research in Science and Technology

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Published

2015-08-30

Issue

Volume 1, Issue 3, July-August-2015

Section

Research Articles

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Copyright (c) IJSRST

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Vaibhav N. Nagre, Omprasad S. Niyakal, Archana R. Dhole, C.S. Magdum, " Formulation and Evaluation of Fast Dissolving Tabletes of Candesartan using Natural Excipients for the Treatment of Hypertension, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 1, Issue 3, pp.170-175, July-August-2015.