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Ion Channels Association with Diseases and their Role as Therapeutic Targets in Drug Discovery
Authors(2) :-Mahin Ghorbani, Hamed Karimi
Ion channels as potential drug targets has been widely designated in pharmaceutical industries for treatment of life threatening diseases .This targeting is a challenging area in drug development and discovery because of availability of extensive knowledge of structures and functions about ion channels such as sodium and calcium voltage-gated ion channels found in mammals. These knowledge mostly obtained on the basis of 3-D crystallographic studies along with their computational analysis. Analysis and modulation of Ion channels provide us with understanding of various properties, such as channel opening, pore function, voltage sensing and ion selectivity. Any disruption and dysregulation in the mentioned functions leads to pathological states thus supporting the idea of their choice as valid targets in drug discovery projetcs.In this paper we focused on importance of ion channels in drug discovery and reviewed their structures and functions and their role in disease and drug discovery and their modulation technologies in drug discovery for their targeting purpose.
Mahin Ghorbani, Hamed Karimi
Ion channel, target, drug discovery, pathology. Modulation of Ion channels
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Published in : Volume 1 | Issue 3 | July-August 2015
Date of Publication : 2015-08-25
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 65-69
Manuscript Number : IJSRST151310
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Mahin Ghorbani, Hamed Karimi , "Ion Channels Association with Diseases and their Role as Therapeutic Targets in Drug Discovery", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 1, Issue 3, pp.65-69, July-August-2015.
Journal URL : http://ijsrst.com/IJSRST151310