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Role of Microarray Technology in Diagnosis and Classification of Malignant Tumours

Authors(2) :-Mahin Ghorbani, Hamed Karimi

Typical cancer research including diagnosis and classification of tumours performed via clinical , cytological and histopathologically methods .However, some cases show diagnostic disturbances due to inadequate clinical information and aberrant histopathological characters which together demonstrated the disadvantages of typical cancer research in the mentioned branches . Recently, development of microarray technology and gene expression profiles emerged for diagnosis and classification of tumours .This technology could overcome some disadvantages of conventional methods of diagnosis and classification and covered some aspects of unresolved tumour's problems. In this review, we focused on recent discoveries in tumour's diagnosis and classification via microarray technology and importance of this technology in cancer research area. Some important types of cancers recently analysed via microarray technology and reviewed in this paper are such as oral cancers, ovarian cancers, colorectal carcinomas, melanomas and prostate carcinoma and breast cancer. Also classification of some tumours using microarray technology discussed here for emphasis the prominent role of microarray technology in cancer research.
Mahin Ghorbani, Hamed Karimi
Microarray Technology, Gene Expression Profile, Cancer Research, Diagnosis, Classification of Tumours.
  1. Ghorbani M and Karimi H. Cyclin-Dependent Kinases as valid targets for cancer treatment. Journal of Pharmacy Research 2015,9(6),377-382
  2. Hoguen Kim, Role of Microarray in Cancer Diagnosis ,Cancer Res Treat. 2004 Feb; 36(1): 1-3.
  3. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577-580.
  4. ].Kim NG, Kim JJ, Ahn JY, Seong CM, Noh SH, Kim CB, Min JS, Kim H. Putative chromosomal deletions on 9P, 9Q and 22Q occur preferentially in malignant gastrointestinal stromal tumors. Int J Cancer. 2000;85:633-638.
  5. ].Choi YR, Kim H, Kang HJ, Kim NG, Kim JJ, Park KS, Paik YK, Kim HO, Kim H. Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. Cancer Res. 2003;63:2188-2193.
  6. Harder L, Gesk S, Martin-Subero JI, Merz H, Hochhaus A, Maass E, Feller A, Grote W, Siebert R, Fetscher S. Cytogenetic and molecular characterization of simultaneous chronic and acute myelocytic leukemia. Cancer Genet Cytogenet. 2003;142:80-82
  7. Shridhar V, Lee J, Pandita A, Iturria S, Avula R, Staub J, Morrissey M, Calhoun E, Sen A, Kalli K, Keeney G, Roche P, Cliby W, Lu K, Schmandt R, Mills GB, Bast RC, Jr, James CD, Couch FJ, Hartmann LC, Lillie J, Smith DI. Genetic analysis of early-versus late-stage ovarian tumors. Cancer Res. 2001;61:5895-5904.
  8. Alevizos I, Mahadevappa M, Zhang X, Ohyama H, Kohno Y, Posner M, Gallagher GT, Varvares M, Cohen D, Kim D, Kent R, Donoff RB, Todd R, Yung CM, Warrington JA, Wong DT. Oral cancer in vivo gene expression profiling assisted by laser capture micro-dissection and micro-array analysis. Oncogene. 2001;20:6196-6204.
  9. de Wit NJ, Burtscher HJ, Weidle UH, Ruiter DJ, van Muijen GN. Differentially expressed genes identified in human melanoma cell lines with different metastatic behaviour using high density oligonucleotide arrays. Melanoma Res. 2002;12:57-69.
  10. Kitahara O, Furukawa Y, Tanaka T, Kihara C, Ono K, Yanagawa R, Nita ME, Takagi T, Nakamura Y, Tsunoda T. Alterations of gene expression during colorectal carcinogenesis revealed by cDNA micro-arrays after laser-capture micro-dissection of tumor tissues and normal epithelia. Cancer Res. 2001;61:3544-3549.
  11. Birkenkamp-Demtroder K, Christensen LL, Olesen SH, Frederiksen CM, Laiho P, Aaltonen LA, Laurberg S, Sorensen FB, Hagemann R, Orntoft TF. Gene expression in colorectal cancer. Cancer Res. 2002;62:4352-4363.
  12. Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, Moskaluk CA, Frierson HF, Jr, Hampton GM. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res. 2001;61:5974-5978.
  13. Giordano TJ, Shedden KA, Schwartz DR, Kuick R, Taylor JM, Lee N, Misek DE, Greenson JK, Kardia SL, Beer DG, Rennert G, Cho KR, Gruber SB, Fearon ER, Hanash S. Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol. 2001;159:1231-1238.]
  14. Kumar R, Sharma A, and Rajesh R. K, Application of microarray in breast cancer: J Pharm Bioallied Sci. 2012 Jan-Mar; 4(1): 21-26.
  15. Rodenhiser DI, Andrews J, Kennette W, Sadikovic B, Mendlowitz A, Tuck AB, et al. Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays. Breast Cancer Res. 2008;10:R62.
  16. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286:531-537.
  17. Giordano TJ, Shedden KA, Schwartz DR, Kuick R, Taylor JM, Lee N, Misek DE, Greenson JK, Kardia SL, Beer DG, Rennert G, Cho KR, Gruber SB, Fearon ER, Hanash SOrgan-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol. 2001 Oct;159(4):1231-8
  18. Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O'Connell JX, Zhu S, Fero M, Sherlock G, Pollack JR, Brown PO, Botstein D, van de Rijn M. Molecular characterization of soft tissue tumors: a gene expression study. Lancet. 2002; 359:1301-1307.
Publication Details
  Published in : Volume 1 | Issue 3 | July-August 2015
  Date of Publication : 2015-08-25
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 117-121
Manuscript Number : IJSRST151318
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Mahin Ghorbani, Hamed Karimi, "Role of Microarray Technology in Diagnosis and Classification of Malignant Tumours", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 1, Issue 3, pp.117-121, July-August-2015
URL : http://ijsrst.com/IJSRST151318