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Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery

Authors(2) :-Mahin Ghorbani, Hamed Karimi

G-Protein Coupled Receptors as the largest class of cell surface signaling proteins are widely considered in drug discovery programs as therapeutic drug targets; their contribution in drug discovery process is because of their critical role in many physiological functions and their link with emerging different types of diseases including cancer development and cancer metastasis. Their association to hereditary diseases, made them important for examination as novel targets too. As they constitute the target of 50% of the available therapeutic agents in the market, they are still most attractive potential targets for developing new drugs especially anti-cancer drugs. Their structure function relationship have been made them a powerful basis for screening a large number of pharmaceutical products. In this paper we purpose to review significant role of the GPCRs in cancer development and drug discovery along with the information regarding their structure, classification and recent studies and findings about their position as drug targets. This review provides scientists for development of favorable opportunities for drug discovery in cancer research including prevention and diagnosis and treatment.
Mahin Ghorbani, Hamed Karimi
Corporation of G-Protein Coupled Receptors, Drug Target, Drug Discovery, Associated Disesaeas, Cancer
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Publication Details
  Published in : Volume 1 | Issue 3 | July-August 2015
  Date of Publication : 2015-08-25
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 122-126
Manuscript Number : IJSRST151321
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Mahin Ghorbani, Hamed Karimi, "Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 1, Issue 3, pp.122-126 , July-August-2015.
Journal URL : http://ijsrst.com/IJSRST151321

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