Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery

Authors

  • Mahin Ghorbani  Department of Biotechnology, Fergusson College, F.C. Road, Pune, Maharashtra, India
  • Hamed Karimi  Department of Information Technology, Payam Noor University of Farokh-shahr, Farokh-shahr, Chaharmahl va bakhtiari, Iran

Keywords:

Corporation of G-Protein Coupled Receptors, Drug Target, Drug Discovery, Associated Disesaeas, Cancer

Abstract

G-Protein Coupled Receptors as the largest class of cell surface signaling proteins are widely considered in drug discovery programs as therapeutic drug targets; their contribution in drug discovery process is because of their critical role in many physiological functions and their link with emerging different types of diseases including cancer development and cancer metastasis. Their association to hereditary diseases, made them important for examination as novel targets too. As they constitute the target of 50% of the available therapeutic agents in the market, they are still most attractive potential targets for developing new drugs especially anti-cancer drugs. Their structure function relationship have been made them a powerful basis for screening a large number of pharmaceutical products. In this paper we purpose to review significant role of the GPCRs in cancer development and drug discovery along with the information regarding their structure, classification and recent studies and findings about their position as drug targets. This review provides scientists for development of favorable opportunities for drug discovery in cancer research including prevention and diagnosis and treatment.

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International Journal of Scientific Research in Science and Technology

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Published

2015-08-25

Issue

Volume 1, Issue 3, July-August-2015

Section

Research Articles

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How to Cite

[1]
Mahin Ghorbani, Hamed Karimi, " Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 1, Issue 3, pp.122-126 , July-August-2015.