Home > Archives > IJSRST15138 IJSRST-Library

Role of Aquaporins in Diseases and Drug Discovery

Authors(2) :-Mahin Ghorbani, Hamed Karimi

Aquaporins as water channels in transportation of water in and out of the cells due to their water permeability property play an important role in maintaining water's constancy which result in normal human physiology. Any mutation of the genes encoding them result in causing many diseases which are life threatening and dangerous like hyperinsulinemia,Sjogren's syndrome,vasogenic brain edema, glaucoma,nephrogenic diabetes insipidus, carcinoma ,lymph node metastatic carcinoma and tumor growth, etc . Recent studies and discoveries has shown that aquaporins have fundamental role in drug discovery and they serves as attractive targets for different diseases. Several types of aquaporins are discovered which play important role in different types of diseases and drug discovery .In this paper we focused on role of aquaporins , structure- function relationship , types of aquaporins and their related diseases and strategies for identification of modulators of these drug targets for discovery of novel therapies and recent discoveries on different types of aquaporins and introduction of them as attractive targets. These paper showed significant role of aquaporins in normal human physiology and pathophysiology and give insights for deserving attention for them to effectively treat some of life threatening diseases.
Mahin Ghorbani, Hamed Karimi
Aauaporins, Diseases, drug discovery, Target, physiology and pathophysiology
  1. Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. Prog Histochem Cytochem. 2004;39(1):1-83
  2. Verkman AS, Mitra AK. Structure and function of aquaporin water channels. Am J Physiol Renal Physiol. 2000 Jan;278(1):F13-28.
  3. Rastogi .S. C., Rastogi P and Mendiratta N.,2008. Bioinformatics Methods and Applications: Genomics .Proteomics And Drug Discovery PHI Learning Pvt. Ltd
  4. Nemeth-Cahalan KL, Clemens DM, Hall JE.Regulation of AQP0 water permeability is enhanced by cooperativity. J Gen Physiol. 2013 Mar;141(3):287-95. .
  5. Maunsbach AB, Marples D, Chin E, Ning G, Bondy C, Agre P, Nielsen S.Aquaporin-1 water channel expression in human kidney. J Am Soc Nephrol. 1997 Jan;8(1):1-14.
  6. Knepper MA, Inoue T. Regulation of aquaporin-2 water channel trafficking by vasopressin. Curr Opin Cell Biol. 1997 Aug;9(4):560-4.
  7. Wesche D, Deen PM, Knoers NV.Congenital nephrogenic diabetes insipidus: the current state of affairs. Pediatr Nephrol. 2012 Dec;27(12):2183-204.
  8. Seleit I, Bakry OA, Sharaky DA, Ragheb E. Evaluation of Aquaporin-3 Role in Nonmelanoma Skin Cancer: An Immunohistochemical Study. Ultrastruct Pathol. 2015 Jun 24:1-12.
  9. Hara-Chikuma M, Satooka H, Watanabe S, Honda T, Miyachi Y, Watanabe T, Verkman AS. Aquaporin-3-mediated hydrogen peroxide transport is required for NF-?B signalling in keratinocytes and development of psoriasis. Nat Commun. 2015 Jun 23;6:7454.
  10. Wang Y, Huang J, Ma Y, Tang G, Liu Y, Chen X, Zhang Z, Zeng L, Wang Y, Ouyang YB, Yang GY.MicroRNA-29b is a therapeutic target in cerebral ischemia associated with aquaporin 4. J Cereb Blood Flow Metab. 2015 Jul 1. doi: 10.1038/jcbfm.2015.156.
  11. Song T, Yang H, Ho JC, Tang SC, Sze SC, Lao L, Wang Y, Zhang KY. Expression of aquaporin 5 in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer. Oncol Lett. 2015 Jun;9(6):2799-2804.
  12. Tran TL, Bek T, Holm L, la Cour M, Nielsen S, Prause JU, Rojek A, Hamann S, Heegaa S.Aquaporins 6-12 in the human eye. Acta Ophthalmol. 2013 Sep;91(6):557-63.
  13. Matsuki-Fukushima M, Fujita-Yoshigaki J, Murakami M, Katsumata-Kato O, Yokoyama M, Sugiya H. Involvement of AQP6 in the Mercury-sensitive osmotic lysis of rat parotid secretory granules. J Membr Biol. 2013 Mar;246(3):209-14
  14. Prieto Marinez N, Vilagran I, Morato R, Rodriguez-Gil JE, Yeste M, Bonet S. Aquaporins 7 and 11 in boar spermatozoa: detection, localisation and relationship with sperm quality. Morishita YReprod Fertil Dev. 2014 Oct 31. doi: 10.1071/RD14237. Epub ahead of print]
  15. Calamita G, Mazzone A, Bizzoca A, Cavalier A, Cassano G, Thomas D, Svelto M. Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract. Eur J Cell Biol. 2001 Nov;80(11):711-9.
  16. Rodriguez A, Gena P, Mendez-Gimenez L, Rosito A, Valenti V, Rotellar F, Sola I, Moncada R, Silva C, Svelto M, Salvador J, Calamita G, Fruhbeck G. Reduced hepatic aquaporin-9 and glycerol permeability are 16.related to insulin resistance in non-alcoholic fatty liver disease. Int J Obes (Lond). 2014 Sep;38(9):1213-20..
  17. Laforenza U, Scaffino MF, Gastaldi G. Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. PLoS One. 2013;8(1):e54474.
  18. Ishii M, Ohta K, Katano T, Urano K, Watanabe J, Miyamoto A, Inoue K, Yuasa H. Dual functional characteristic of human aquaporin 10 for solute transport. Cell Physiol Biochem. 2011;27(6):749-56
  19. Gorelick DA, Praetorius J, Tsunenari T, Nielsen S, Agre P. Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. BMC Biochem. 2006 May 1;7: 14.
  20. Matsuzaki T, Hara-chikuma M, Andoo A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol. 2005 Sep;25(17):7770-9.
  21. Itoh T, Rai T, Kuwahara M, Ko SB, Uchida S, Sasaki S, Ishibashi K. Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Commun. 2005 May 13;330(3):832-8.
Publication Details
  Published in : Volume 1 | Issue 3 | July-August 2015
  Date of Publication : 2015-08-25
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 60-64
Manuscript Number : IJSRST15138
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Mahin Ghorbani, Hamed Karimi, "Role of Aquaporins in Diseases and Drug Discovery", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 1, Issue 3, pp.60-64, July-August-2015.
Journal URL : http://ijsrst.com/IJSRST15138

Article Preview