A Review on Anticancer Drug from Marine

Authors(5) :-Omkar A Patil, Prajkta S Patil, Trupti D Dudhgaonkar, Shriniwas K Mohite, Chandracanth S Magdum

The marine environment is a rich source of both biological and chemical diversity. It is very much likely that marine organisms would be wonderful source of biologically active molecules The collection of the marine therapeutics includes molecules with antibiotic, antiviral, antiphrastic, analgesic and anticancer agent from bacteria, cyanobacteria, tunica, fungi, sponge This reviewfocuses on the latest studies and critical research in this field and evidences the immense potential ofmarine organisms as sources of bioactive peptides and other anticancer biomolecules Various anticancer compounds like Aplidine, Bryostatin-1, Didemin B, Dolastation, Ecteinascidine with diverse modes of action, such as, anti-proliferative, antioxidant, anti-microtubule havebeen isolated from marine sources. Traditional chemotherapeutic agents have a range of side effects likefatigue, gastrointestinal distress and depression of immune system which introduces the these sources have been shown to have antioxidantactivity and cytotoxic effect on several human cancers such as leukemia, lymphoma, ovarian, melanoma, breast, bladder, neuroendocrine, prostatic, colon and non-small cell lung cancer very potently.

Authors and Affiliations

Omkar A Patil
Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
Prajkta S Patil
Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
Trupti D Dudhgaonkar
Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
Shriniwas K Mohite
Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
Chandracanth S Magdum
Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India

Marine Organisms, Bryostatin-1, Dolastation, Human Cancers

  1. Wender PA, Hinkle KW, Koehler MF, Lippa B. The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues. Med Res Rev 1999; 19(5): 388-407.
  2. Wall NR, Mohammed RM, Nabha SM, et al. Modulation of Ciap-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in human early pre-B acute lymphoblastic leukemia cell line REH. Biochem Biophys Res Commun 1999; 266: 76-80.
  3. Trenn G, Pettit GR, Takayama H, et al. Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins. J Immunol 1988; 140: 433—439.
  4. Hornung RL, Pearson JW, Beckwith M, Longo DL. Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro and in vivo activity.Cancer Res 1992; 52(1): 101-107.
  5. Varterasian ML, Mohammad RM, Eilender DS, et al. Phase I study of bryostatin-1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia. J Clin Oncol 1998; 16(1): 56-62.
  6. Basu A, Lazo JS. Sensitization of human cervical carcinoma cells to cis diamminedichloroplatinum(II) by bryostatin 1. Cancer Res 1992; 52(11): 3119-3129.
  7. Jayson GC, Crowther D, Prendiville J, et al. A phase I trial of bryostatin 1 in patients with advanced malignancies using a 24 hour intravenous infusion. Br J Cancer 1995; 72: 461-468.
  8. Prendiville J, Crowther D, Thatcher N, et al. A phase I study of intravenous bryostatin 1 in patients with advanced cancer. Br J Cancer 1993; 68: 418-424.
  9. Faivre, S.; Chieze, S.; Delbaldo, C.; Ady-Vago, N.; Guzman, C.; Lopez-Lazaro, L.; Lozahic, S.; Jimeno, J.; Pico, F.; Armand, J.; et al. Phase I and pharmacokinetic study of aplidine, a new marine cyclodepsipeptide in patients with advanced malignancies. Clin. Oncol. 2005, 23, 7871–7880.
  10. Garcia-Fernandez, L.F. et al. (2002) Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase Cδ. Oncogene 21, 7533–7544.
  11. Broggini, M.; Marchini, S.V.; Galliera, E.; Borsotti, P.; Taraboletti, G.; Erba, E.; Sironi, M.; Jimeno, J.; Faircloth, G.T.; Giavazzi, R.; et al. Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4. Leukemia 2003, 17, 52–59.
  12. Armand, J.-V.; Ady-Vago, N.; Faivre, S. Phase I and Pharmacokinetic Study of Aplidine (apl) Given as a 24-Hour Continuous Infusion Every Other Week (q2w) in Patients (pts) with Solid Tumor (st) and Lymphoma (NHL). In Proceedingof 2001 ASCO Annual Meeting; American Society of Clinical Oncology: San Francisco, CA, USA,2001.
  13. Bai, R., Friedman, S. J., Pettit, G. R. & Hamel, E. Dolastatin-15, a potent antimitotic depsipeptide derived from Dolabella auricularia: interaction with tubulin and effects on cellular microtubules. Pharmacol. 43, 2637–2645 (1992).
  14. García-Rocha, M.; Bonay, P.; Avila, J. The antitumoral compound Kahalalide F acts on celllysosomes. Cancer Lett. 1996, 99, 43–50.
  15. Faircloth, G.T.; Smith, B.; Grant, W. Selective antitumor activity of Kahalalide F, a marine derived cyclic depsipeptide. Am. Assoc.Cancer Res. 2001, 42, 1140
  16. Pettit GR, et al. The isolation and structure of a remarkable marine animal amineoplastic constituent: Dolastatin 10. J Am Chem Sec 1987; 109: 6883-6885.
  17. Bai R, Pettit GR, Hamel E. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. Biochem Pharmacol 1990; 39(12): 1941-1949
  18. Pathak S, Multani AS, Ozen M, et al. Dolastatin-10 induces polyploidy, telomeric associations and apoptosis in a murine melanoma cell line. Oncol Rep 1998; 5(2): 373-376.
  19. Maki A, Mohammad R, Raza S, et al. Effect of dolastatin 10 on human non-Hodgkin lymphoma cell lines. Anticancer Drugs 1996; 7(3): 344-350.
  20. Anticancer agent: a phase I clinical, pharmacological and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res 2000; 6: 1293-130.
  21. McElroy EA, Pitot HC, Erlichman C, et al. Phase I trial of dolastatin-10 in patients with advanced solid tumors. Proc Am Soc Clin Oncol 1997; abstr. #782.
  22. Minuzzo M, Marchini S, Broggini M, Faircloth G, D'incalci M And Mantovani R: Interference of transcriptional activation by the anti-neoplastic drug ET-743. Natl.Acad.Sci.USA. 2000, 97: 6780-6784
  23. Jin S, Gorfajn B, Faircloth G And Scotto K: Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. Natl.Acad.Sci.USA. 2000, 97, 6775-6779.
  24. Friedman D, Hu Z, Kolb EA, Gorfajn B And Scotto KW: Ecteinascidin-743 inhibits activated but not constitutive transcription. Cancer Res. 2002, 62, 3377-3381.
  25. Kanzaki A, Takebayashi Y, Ren XQ, Akiyama S., Bates S., Pommier Y., : Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743. Mol Cancer Ther. 2002, 1, 1327-1334.
  26. Damia G; Silvestri S; Carrassa L; Filiberti L; Faircloth G T; Liberi G; Foiani M; D'Incalci M:Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer. 2001, 92, 583-588.
  27. Takebayashi Y; Pourquier P; Zimonjic D B; Nakayama K; Emmert S; Ueda T; Urasaki Y; Kanzaki A; Akiyama S I; Popescu N; Kraemer K H; Pommier Y: Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med. 2001, 7, 961-966. 30 D'incalci M, Colombo T, Ubezio P., Nicoletti I., Giavazzi R., Erba E., Ferrarese L., Meco D.,Riccardi R., Sessa C., Cavallini E., Jimeno J., Faircloth G: The combination of yondelis and cisplatin is synergistic against human tumor xenografts. Eur J Cancer. 2003, 39, 1920-1926.
  28. Sarries C., Haura E., Roig B. Pharmacogenomic strategies for developing customized chemotherapy in non-small cell lung cancer. 2002, 3(6), 763-780.
  29. Taamma A, Misset JL, Riofrio M, Guzman C, Brain E, Lopez Lazaro L, Rosing H, Jimeno J, Cvitkovic E.: Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol. 2001, 19, 1256-1265.
  30. Ryan DP, Supko JG, Eder JP, Seiden M, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW: Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res. 2001, 7, 231-242.
  31. Villalona-Calero MA, Eckhardt SG, Weiss G, Hidalgo M, Beijnen JH, van Kesteren C, Rosing H, Campbell E, Kraynak M, Lopez-Lazaro L, Guzman C, Von Hoff DD, Jimeno J, Rowinsky EK.: A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res. 2002, 8, 75-85.
  32. Twelves C., Hoekman K., Bowman A., Vermorken J.B., Anthoney A., Smyth J., Van Kesteren C., Beijnen J.H., Uiters J., Wanders J., Gomez J., Guzmán C., Jimeno J., Hanauske A..: Phase I and pharmacokinetic study of Yondelis (Ecteinascidin 743; ET-743) administered as an infusion over 1h or 3h every 21 days in patients with solid tumors. Eur J Cancer. 2003, 39, 1842-1851.
  33. Delaloge S, Yovine A, Taamma A, Riofrio M, Brain E, Raymond E, Cottu P, Goldwasser F,Jimeno J, Misset JL, Marty M, Cvitkovic E. Ecteinascidin-743: a marine-derived compound inadvanced, pretreated sarcoma patients-preliminary evidence of activity. J Clin Oncol. 2001,19(5), 1248-1255.
  34. Demetri G., Manola J., Harmon D., Maki R., Seiden R., Supko J., Ryan D., Puchlaski T., Goss G., Merriam P., Waxman A., Slater S., Potter A., Quigley T., Lopez T., Sancho MA., Guzman C., Jimeno J., Garcia Carbonero R. Ecteinascidin-743 (ET-743) induces durable responses and promising 1-year survival rates in soft tissue sarcomas (STS): Final results of Phase II and Pharmacokinetic studies in the U.S.A American Society of Clinical Oncology, San Francisco, CA, May 12 –15,. Procc. 352a. Abstract 1406.
  35. Le Cesne A., Blay J.,. Judson I, Van Oosterom A, Verweij J, Radford J, Lorigan P, Rodenhuis S, Donato De Paola E, Van Glabbeke M., Jimeno J., Nielsen O. ET-743 is an active drug in adult soft-tissue sarcoma: a STBSG-EORTC Phase II trial. American Society of Clinical Oncology,
  36. The Annual Meeting . San Francisco, CA, May 12 – 15, Procc. 353a. Abstract 1407.
  37. Yovine A., Riofrio M., Brain E., Blay JY., Kahatt C., Delaloge S., Beautier L., Cottu P., Jimeno J., Cvitkovic E., Misset JL. Ecteinascidin-743 given as a 24 hour (H) intravenous continuos infusion (IVCI) every 3 weeks: results of a Phase II trial in patients (PTS) with pretreated soft tissue sarcomas (PSTS). American Society of Clinical Oncology. 37th Annual Meeting . San Francisco, CA, May 12 – 15, 2001. Proc. 363a. Abstract 1449.
  38. Jimeno J., Maki R., Casali P., Faircloth G., Martinez N., Nieto A., Cañigueral S. Therapeutic impact of ET-743 (Yondelis®, Trabectidin) a new marine derived compound in Sarcoma.Current Opinion in Orthopedics. Submitted September 2003.solid tumors. Eur J Cancer. 2003, 39, 1842-1851

Publication Details

Published in : Volume 2 | Issue 4 | July-August 2016
Date of Publication : 2016-08-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 236-242
Manuscript Number : IJSRST1622111
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Omkar A Patil, Prajkta S Patil,Trupti D Dudhgaonkar, Shriniwas K Mohite, Chandracanth S Magdum, " A Review on Anticancer Drug from Marine", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 4, pp.236-242, July-August-2016.
Journal URL : http://ijsrst.com/IJSRST1622111

Article Preview