Microwave Assisted Synthesis, Characterization and Antibacterial Activity of 2- Chloromethyl Benz Imidazole Derivatives

Authors

  • Ruchita A Patil  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
  • Sharmila T Patil  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
  • Trupti D Dudhgaonkar  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
  • Archana R Dhole  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
  • Shriniwas K Mohite  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India
  • Chandrakant S Magdum  Rajarambapu College of Pharmacy, Kasegaon, Kasegaon, Walwa, Sangali, Maharashtra, India

Keywords:

2-Chloromethyl Benzimidazole, O-Phenylenediamine, Chloroacetic Acid Aniline.

Abstract

Objective-the objective of present research work to synthesize and screen novel 2-chloromethyl-1-h-benzimidazole derivative for antibacterial activity. Method-2-chloromethyl-1-H-benzimidazole was prepared by condensing 2-chloromethyl-1-h-benzimidazole with different aromatic amines and heterocyclic. The synthesized compounds were screened for their antibacterial activity against stap. Aurious by well plate method. 2-chioromethyl benzimidazole can be synthesized by the reaction of o-phenylenediamine with chloroaceticacid. This on reaction with substituted anilines in presence of ethanolic KOH gives corresponding benzimidazolederivatives. The synthesized compounds were characterized by TLC & IR data.

References

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International Journal of Scientific Research in Science and Technology

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Published

2016-08-30

Issue

Volume 2, Issue 4, July-August-2016

Section

Research Articles

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How to Cite

[1]
Ruchita A Patil, Sharmila T Patil, Trupti D Dudhgaonkar, Archana R Dhole, Shriniwas K Mohite, Chandrakant S Magdum, " Microwave Assisted Synthesis, Characterization and Antibacterial Activity of 2- Chloromethyl Benz Imidazole Derivatives, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 2, Issue 4, pp.243-249, July-August-2016.