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Microwave Assisted Synthesis, Characterization and Antibacterial Activity of 2- Chloromethyl Benz Imidazole Derivatives

Authors(6) :-Ruchita A Patil, Sharmila T Patil, Trupti D Dudhgaonkar, Archana R Dhole, Shriniwas K Mohite, Chandrakant S Magdum

Objective-the objective of present research work to synthesize and screen novel 2-chloromethyl-1-h-benzimidazole derivative for antibacterial activity. Method-2-chloromethyl-1-H-benzimidazole was prepared by condensing 2-chloromethyl-1-h-benzimidazole with different aromatic amines and heterocyclic. The synthesized compounds were screened for their antibacterial activity against stap. Aurious by well plate method. 2-chioromethyl benzimidazole can be synthesized by the reaction of o-phenylenediamine with chloroaceticacid. This on reaction with substituted anilines in presence of ethanolic KOH gives corresponding benzimidazolederivatives. The synthesized compounds were characterized by TLC & IR data.
Ruchita A Patil, Sharmila T Patil, Trupti D Dudhgaonkar, Archana R Dhole, Shriniwas K Mohite, Chandrakant S Magdum
2-Chloromethyl Benzimidazole, O-Phenylenediamine, Chloroacetic Acid Aniline.
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Publication Details
  Published in : Volume 2 | Issue 4 | July-August 2016
  Date of Publication : 2016-08-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 243-249
Manuscript Number : IJSRST1622112
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Ruchita A Patil, Sharmila T Patil, Trupti D Dudhgaonkar, Archana R Dhole, Shriniwas K Mohite, Chandrakant S Magdum, "Microwave Assisted Synthesis, Characterization and Antibacterial Activity of 2- Chloromethyl Benz Imidazole Derivatives", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 4, pp.243-249, July-August-2016
URL : http://ijsrst.com/IJSRST1622112