Comparative Formulation and Evaluation of Fast Dissolving Candesartan Tablet Using Natural Superdisintegrants

Authors(3) :-Swati S. Talokar, Rohan R Vakhariya, Archana R. Dhole

Candesartan is used commonly for the treatment of hypertension. It has half-life of 9 hrs whereas T max is 3-4 hr. As Candesartan is water insoluble drug this adversely affects bioavailability and bioequivalence.In present study efforts are made to reduce its disintegrating time using Plantago ovata and Sodium starch glycolate as comparative superdisintegrnats.. The objective of the present study was to prepare the fast dissolving tablet of candesartan using different natural superdisintegrants like Plantago ovata, , Sodium Starch Glycolate, . Hardness, friability, weight variation, wetting time, thickness, water absorption ratio, disintegrating time, uniformity of content and in-vitro drug release were checked for evaluation purpose.

Authors and Affiliations

Swati S. Talokar
Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India
Rohan R Vakhariya
Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India
Archana R. Dhole
Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist Sangli, Maharashtra, India

Candesartan celixitil, superdisintegrants, starch glycolate, plantago ovate

  1. Vaibhav N. Nagre*, Omprasad S.Niyakal, Archana R.Dhole, C.S. Magdum Formulation and Evaluation of Fast Dissolving Tabletes of Candesartan using Natural Excipients for the Treatment of Hypertension 2015 IJSRST | Volume I pg.no.170
  2. Basawaraj S.Patil1*, N.G.Raghavendra Rao2 Formulation and Evaluation of fast dissolving tablets of candesartan cilexetil using natural and synthetic superdisintegrants 250 | J App Pharm 03(03): 250-261 (2011)
  3. *Harish Gopinath3, Kasi Sankar Venugopal1, Disintegrants- a brief review

Publication Details

Published in : Volume 2 | Issue 3 | May-June 2016
Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 206-211
Manuscript Number : IJSRST162331
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Swati S. Talokar, Rohan R Vakhariya, Archana R. Dhole, " Comparative Formulation and Evaluation of Fast Dissolving Candesartan Tablet Using Natural Superdisintegrants, International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 3, pp.206-211, May-June-2016. Available at doi : 10.32628/IJSRST162331
Journal URL : http://ijsrst.com/IJSRST162331

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