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Association of Oxalobacter Formigenes with the Stools of Urinary Tract Stone Patients In Basrah Province

Authors(2) :-Nooraldeen A. Jasim, Munaff J. Abd Al-Abbas

One hundred stool samples were obtained, fifty (30 from male and 20 from female) from patients with urinary stone disease and the other fifty from healthy individuals (38 from male and 12 from female) as a control. The incidence of urolithiasis was more in males (60%), kidney (74%), ureter (24%) and bladder (2%). Calcium-oxalate stone was higher (74%) than non-oxalate stone. Specific oxc gene for Oxalobacter formigenes was detected in 96 % of healthy samples comparing with patients. Between stone types, Calcium- oxalate was 74% in patients which have only 24.3% oxc comparison with 75.7% negative, while non - calcium oxalate ( 26%) was in patients with 69.2% of oxc. The last results showing the positive role of Oxalobacter formigenes to reduce the calcium-oxalate stone formation in Basrah province.
Nooraldeen A. Jasim, Munaff J. Abd Al-Abbas
Oxalobacter Formigenes, Stone, Basrah, Urinary
  1. Mittal, R.D. and Kumar, R. (2004). Gut-inhabiting bacterium Oxalobacter formignes: role in calcium oxalate urolithiasis. J. Endourol. 18: 418-424.
  2. Jan, H., Akbar, I., Kamran, H. and Khan J. ( 2008 ). Frequency of renal stone disease in patients with urinary tract infection. J. Ayub. Med. Coll. Abbottabad. 20: 60-62.
  3. 3.Yagisawa, T., Hayashi, T., Yoshida, A., Okuda, H., Kobayashi, H., Ishikawa, N., Goya, N. and Toma, H. (1999). Metabolic characteristics of the elderly with recurrent calcium oxalate stones. BJU. Int. 83: 924-928.
  4. Ullah, I., Alam, K., Wazir, B. G., Shah, F., Khan, S. A. and Malik, A. (2012 ). Chemical composition of urinary tract stones: Experience at a  referral center of Khyber Pakhtukhwa province. Ann. Pak. Inst. Med. Sci. 8: 31-34.
  5. Grases, F., Costa-Bauza, A. and Priento, R. M. (2006). Renal lithiasis and nutrition. Nutr. J. 5: 23.
  6. Parmar, M. S. (2004). Kidney stones. Brit. Med. Journal. 328: 1420-1424.
  7. Qaader, D. S., Yousif, S. Y.and Mahdi, L. K. (2006). Prevalence and etiology of urinary stones in hospitalized patients in Baghdad. East Mediterranean. Health. J. 6: 853- 860 .
  8. Siener, R., Bangen, U., Sidhu, H., Honow, R., Von Unruh, G. and  Hesse, A. (2013). The role of oxalobacter formegens colonization in calcium oxalate stone disease. Kid. Int. 83: 1144-1149.
  9. Siener, R., Ebert, D. and Hesse, A. (2001). Urinary oxalate excretion in female calcium oxalate stone formers with and without a history of recurrent urinary tract infections. Urol. Res. 29: 245-248.
  10. Stewart, C. S., Duncan, S. H. and Cave, D. R. (2004). Oxalobacter formigenes and its role in oxalate metabolism in human gut. FEMS. Microbiol. Lett. 230: 1-7.
  11. Abratt, V. R. and Reid, S. J. (2010). Oxalate-degrading bacteria of  the human gut as probiotics in the management of kidney stone disease. Adv. Appl. Microbiol. 72: 63-87.
  12. Allison, M. J., Dawson, K. A., Mayberry, W. R. and Foss, J. G. (1985). Oxalobacter formigenes gen. nov., sp. nov.: oxalate-degrading anaerobes that inhabit the gastrointestinal tract. Arch Microbiol. 141: 1-7.
  13. Dawson, K. A., Allison, M. J. and Hartman, P. A. (1980). Characteristics of  anerobic oxalate degrading enrichment cultures from the rumen. Appl. Environ. Microbiol. 40: 840-846 .
  14. Baetz, A. L. and Allison, M. J. (1990). Purification and characterization of formly-coenzyme A transferase from Oxalobacter formigenes. J. Bacteriol. 172: 3537-3540.
  15. Sidhu, H., Allison, M. J. and peak, A. B. (1997). Identification and classification of Oxalobacter formigenes strains by using oligonucleotide probes and primers. J. Clin. Microbiol.35: 350-353.
  16. Baetz, A. L. and Allison, M. J. (1989). Purification and characterization of oxalyl-CoA decarboxylase from Oxalobacter formigenes. J. Bacteriol. 171: 2605-2608.
  17. Lung, H. Y., Baetz, A. L. and Peck, A. B. (1994). Molecular cloning, DNA sequence, and gene expression of the oxalyl-coenzyme A decarboxylase gene, oxc, from the bacterium Oxalobacter formigenes. J. Bacteriol. 176: 2468-2472.
  18. Sidhu, H., Schmidt, M. E., Cornelius, J. G., Thamilselvan, M. and et al. (1999). Direct correlation between hyperoxaluria / oxalate stone disease and the absence of gastrointestinal tract-dwelling bacteria Oxalobacter  formigenes: possible prevention by gut recolonization or enzyme replacement therapy. J. Am. Soc. Nephrol. 10: 334- 340 . 
  19. Duncan, S. H., Richardson, A. J., Kaul, P., Holmes, R. P., Allison, M. J. and Stewart, C. S. (2002). Oxalobacter formigenes and its potential role in human health. Appl. Environ. Microbiol. 68: 3841-3847.
  20. Kaufman, D. W., Kelly, J. P., Curhan, G. C., Anderson, T. E. and et al. (2008). Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones. J. Am. Soc. Nephrol. 19: 1197-1203.
  21. Kwak, C., Jeong, B. C., Lee, J. H., Kim, H. K., Kim, E. C. and Kim, H. H. (2001). Molecular identification of Oxalobacter formigenes with the polymerase chain reaction in fresh or frozen fecal samples. BJU. Int. 88: 627-632.
  22. Tille, P. M. (2014). Bailey and Scott’s : Diagnostic Microbiology, 13 ed. Mosby, Inc., an affiliate of Elsevier Inc. pp: 57-61.
  23. Van-Nostrand, J. D., Junkins, A. D. and  Bartholdi, R. K. (2000). Poor Predictive Ability of Urinalysis and Microscopic Examination to Detect Urinary Tract Infection. Am. J. Clin. Pathol. 113: 709-713.
  24. Stacy-Phipps, S., Mecca, J. J. and Weiss, J. B. (1995). Multiplex PCR assay and simple preparation method for stool specimens detect enterotoxigenic Escherichia coli of DNA during course infection. J. Clinic. Microbiol. 33: 1054-1059.
  25. Safarinejad, M. R. (2007). Adult urolithiasis in a population-based study in Iran: prevalence, incidence, and associated risk factors. Urol. Res. 35: 73-82.
  26. Scales, C. D., Smith, A. C., Hanley, J. M. and et al. (2012). Prevalence of kidney stones in the United States. Eur Urol 62:160.
  27. Tanthanuch, M., Apiwatgaroon, A. and Pripatnanont, C. (2005). Urinary tract calculi in southern Thailand. J. Med. Assoc. Thai. 88 :80-85.
  28. Khan, A. S., Rai, M. E., Gandapur-Pervaiz, A., Shah, A. H., Hussain, A. A. and Siddiq, M. (2004). Epidemiological risk factors and composition of urinary stones in Riyadh Saudi Arabia. J. Ayub. Med. Coll. Abbottabad. 16: 56-58.
  29. Talati, J. J., Tiselius, H., Albala, D. M. and Ye, Z. (2012). Urolithiasis: Basic science and clinical practice. Siprenger,Verlag, London. P.79.
  30. Al-Jebouri, M. M. and Atalah, N. (2012). A study on the interrelationship between renal calculi, hormonal abnormalities and urinary tract infections in Iraqi patients. open. J. Urol. 2: 6-10.
  31. Khalaf, T. T. and Al-Khafaji, Z. M. (2014). Prevalence of Oxalobacter formigenes among the Iraqi population. World, J. Pharm. Pharmaceut. Sci. 7: 165-177.
Publication Details
  Published in : Volume 2 | Issue 3 | May-June 2016
  Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 113-117
Manuscript Number : IJSRST162336
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Nooraldeen A. Jasim, Munaff J. Abd Al-Abbas, "Association of Oxalobacter Formigenes with the Stools of Urinary Tract Stone Patients In Basrah Province", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 3, pp.113-117, May-June-2016
URL : http://ijsrst.com/IJSRST162336