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Protective Effect of Umbelliferone against Doxorubicin Induced Cardiotoxicity in Swiss Albino Rats

Authors(6) :-Sathesh Kanna Velli, Sharmila Salam, Premkumar Thandavamoorthy, Palanisamy Krishnan, Jagan Sundaram, Devaki Thiruvengadam

Doxorubicin (DOX) is widely used as chemotherapeutic agent. Usefulness of this agent is limited due to its cardiotoxic effects. The aim of this study was to investigate the curative effect of Umbelliferone (UMB) against Doxorubicin (DOX) induced cardiotoxicity in albino rats. Biomarkers like LDH, AST, ALT, ALP, CK, along with heart weight index, antioxidant enzymes, lipid profiles and histological examination were assessed to determine the cardio toxicity effect. DOX alone (25mg/kg bw intraperitoneally three times per week for two weeks) administered group exhibited significant increase in LDH, AST, ALT, ALP, CK, FC, FFA and TG levels and decrease in Enzymatic and Non enzymatic antioxidants activities when compared to control group. Oral administration of Umbelliferone (UMB) (30mg/kg bw) treatment daily for two weeks along with DOX significantly attenuated the increased serum biomarkers, reduced hyperlipidemia and restored the tissue antioxidant activities when compared to DOX alone treated group. Histology examination also clearly showed that UMB significantly inhibited the cardiac damage induced by DOX. Based on the results, this study clearly indicates that UMB used as a potent compound against cardiotoxicity induced by DOX.
Sathesh Kanna Velli, Sharmila Salam, Premkumar Thandavamoorthy, Palanisamy Krishnan, Jagan Sundaram, Devaki Thiruvengadam
Doxorubicin, Umbelliferone, cardiotoxicity
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Publication Details
  Published in : Volume 2 | Issue 4 | July-August 2016
  Date of Publication : 2016-08-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 90-97
Manuscript Number : IJSRST162423
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Sathesh Kanna Velli, Sharmila Salam, Premkumar Thandavamoorthy, Palanisamy Krishnan, Jagan Sundaram, Devaki Thiruvengadam , "Protective Effect of Umbelliferone against Doxorubicin Induced Cardiotoxicity in Swiss Albino Rats", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 4, pp.90-97 , July-August-2016
URL : http://ijsrst.com/IJSRST162423