Protective Effect of Umbelliferone against Doxorubicin Induced Cardiotoxicity in Swiss Albino Rats

Authors

  • Sathesh Kanna Velli  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Sharmila Salam  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Premkumar Thandavamoorthy  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Palanisamy Krishnan  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Jagan Sundaram  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Devaki Thiruvengadam   Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India

Keywords:

Doxorubicin, Umbelliferone, cardiotoxicity

Abstract

Doxorubicin (DOX) is widely used as chemotherapeutic agent. Usefulness of this agent is limited due to its cardiotoxic effects. The aim of this study was to investigate the curative effect of Umbelliferone (UMB) against Doxorubicin (DOX) induced cardiotoxicity in albino rats. Biomarkers like LDH, AST, ALT, ALP, CK, along with heart weight index, antioxidant enzymes, lipid profiles and histological examination were assessed to determine the cardio toxicity effect. DOX alone (25mg/kg bw intraperitoneally three times per week for two weeks) administered group exhibited significant increase in LDH, AST, ALT, ALP, CK, FC, FFA and TG levels and decrease in Enzymatic and Non enzymatic antioxidants activities when compared to control group. Oral administration of Umbelliferone (UMB) (30mg/kg bw) treatment daily for two weeks along with DOX significantly attenuated the increased serum biomarkers, reduced hyperlipidemia and restored the tissue antioxidant activities when compared to DOX alone treated group. Histology examination also clearly showed that UMB significantly inhibited the cardiac damage induced by DOX. Based on the results, this study clearly indicates that UMB used as a potent compound against cardiotoxicity induced by DOX.

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International Journal of Scientific Research in Science and Technology

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Published

2016-08-30

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Volume 2, Issue 4, July-August-2016

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Research Articles

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[1]
Sathesh Kanna Velli, Sharmila Salam, Premkumar Thandavamoorthy, Palanisamy Krishnan, Jagan Sundaram, Devaki Thiruvengadam , " Protective Effect of Umbelliferone against Doxorubicin Induced Cardiotoxicity in Swiss Albino Rats, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 2, Issue 4, pp.90-97 , July-August-2016.