Home > Archives > IJSRST162548 IJSRST-Library

Direct Production of Radioiodine-123 from Tellurium with Lowest Level of Iodine Impurity-124

Authors(2) :-Iman Tarik Al-Alawy, Raghad S. Mohammed

Radioiodine is one of the most important radioisotopes uses in the therapeutic and diagnosis of some diseases. The radioactivity emitting from the radioactive isotopes, such as Auger electrons, positrons and gamma rays plays an important role in medical applications. The half-life of radioactive nuclei I-123 with 13.2h is appropriate for treatment and diagnostic. The main production routes, use, , target. Excitations functions for proton for the reactions(p,n), (p,2n), for the production I-123 and I-124 have been evaluated using an experimental of energy of incident particles and cross sections published in the International Atomic Energy Agency (IAEA), especially (EXFOR) library which measured cross sections for different authors and for several years prior to the present. The best reactions for the production of Iodine-123 are the reaction, while the best reactions for the production of Iodine-124 are . The analysis of a complete energy range has been done for each interaction. The cross sections are reproduced in fine steps of incident proton in 0.01MeV intervals with their corresponding error. Impurity levels that appear in the production processes which have the highest medical applications have been calculated. The best area of useful energy range has been chosen by using cyclotron to reduce the appearance of nuclear impurities.
Iman Tarik Al-Alawy, Raghad S. Mohammed
Radioisotope, I-123, I-124, Cross Section, Iodine Production, Impurity
  1. C. Washington. 1946. Availability of Radioactive Isotopes: Announcement from Headquarters, Manhattan Project. Journal of Science and Technology. Vol. 103, No. 2685, P.71.
  2. (IAEA) International Atomic Energy Agency. 2001. Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions. Vienna (2001), No. 1011–4289, P.4.
  3. J. Lynch. 2008. Radioisotopes in Medicine. Technopolis Group The Netherlands. PP.1-37.
  4. M. Lambrecht and A. P. Wolf. 1973. Cyclotron and Short-Lived Halogen Isotopes for Radiopharmaceutical Applications. In New Developments in Radiopharmaceuticals and Labeled Compounds. (IAEA) Vienna, Vol.1, PP. 275-290.
  5. Rault. 2007. Comparison of Image Quality of Different Iodine Isotopes (I-123, I-124 and I-131). Journal of Cancer Biotherapy and Radiopharmaceuticals. Vol. 22, No.3, PP.423–430.
  6. R. I. Narra, R. W. Howehh, R. S. Harapanhalli, K. S. Sastry  and  D. V. Rao. 1992. Radiotoxicity of Some Iodine-123, Iodine-125, and Iodine- 131-Labeled Compounds in Mouse Testes: Implications for Radiopharmaceutical Design. Journal of Nuclear Medicine. Vol.33 No.12, P.2196.
  7. Sheh, J. Koziorowski, J. Balatoni, C. Lom, D. R. Dahl and R. D. Finn. 2000. Low Energy Cyclotron Production and Chemical Separation of no carrier added Iodine-124 from a Reusable, Enriched Tellurium-124 Dioxide/Aluminum Oxide Solid Solution Target. Journal of Radiochimical Acts. Vol.88. PP.169-173.
  8. E. Frey, D. W. Townsend, A. Flattet, R. De Gautarrd, S. Widgren, A. Jeavons, Christin, A. Smith,  A. Long and A. Donath. 1986 .Tomographic imaging of the human thyroid using I-124. Journal of Clinical Endocrinology Metabolism. Vol.63, PP.918-927.
  9. M. Lambrecht, N. Woodhouse, R. Phillips, D. Wolczak, A. Qureshi, D. E. Reyes, C. Graser, S. A1-Yanbawi, A. A1-Rabiah, W. Meyer, W. Marlais, R. Syed, F. Banjar, A. Riilai and S. Miliebari. 1988. Investigational Study of Iodine-124 with a Positron Camera Am. Journal of Physiological Imaging. Vol.3, PP.197-200.
  10. A. Littlefield and N. Thorley. 1974. "Atomic and nuclear physics" 2nd edition, VAV Nostrand Reinhold Company Limited, P.214.
  11. M. Qaim. 2001. Nuclear data for medical applications: an overview, Radiochim. Acta. Journal. Vol. 89, PP.189-196.
  12. C. Barrall, J. E. Beaver, H. B. Hupf and F. F. Rubio. 1981. Production of Curie Quantities of High Purity 1-123 with 15 MeV Protons. Eurepian Journal of Nuclear Medicien6, PP.411-415.
  13. Acerbi, C. Birattari, M. Castiglioni, F. Resmini and M. Villa. 1975a,b. Production of I-123 for Medical Purposes at the Milan AVF Cyclotron. Journal of Applied Radiation and Isotopes. Vol.26, P.741.
  14. Kondo, R. M. Lambrecht and A. P. Wolf. 1977a,b,c,d. Iodine-123 Production for  Radiopharmaceuticals Excitation Functions of the Te-124(p,2n)I-123 and Te-124(p,n)I-124 Reactions and the Effect of Target  Enrichment Radionuclidic Purity. Journal of Applied Radiation and Isotopes. Vol.28, P.395.
  15. Scholten, Z. Kovács, F. Tárkányi and S. M. Qaim. 1995a,b. Excitation functions of Te-124(p,xn)I-124  reactions  from  6 to  31 MeV  with  special  reference 10 to  the production of at a small cyclotron. Journal of Applied Radiation and Isotopes. Vol. 46, No. 4, PP.255–259.
  16. S. Krane. 1988. "Introductory Nuclear Physics", John Wiley and Sons, PP.378-379.
  17. M. Lambrecht and A. P. wolf. 1973. "Cyclotron and Short-Lived Halogen Isotopes for Radiopharmaceutical Applications". In New Developments in Radiopharmaceuticals and Labelled Compounds. Vienna (1973) (IAEA), Vol. 1, PP. 275-290.
  18. Guillaume, R. M. Lambrecht and A. P.Wolf. 1975. Cyclotron Production of Xe-123 and High Purity I-123: A Comparison of Tellurium Targets. International Journal of Applied Radiation Isotopes. Vol. 26, PP.703-707.             
  19. M. Qaim and G. Stocklin. 1983. Production of Some Medically Important Short-Lived Neutron Deficient Radioisotopes of Halogens. Journal of Radiochimica Acts. Vol. 34, PP. 25-40.
  20. G. Clem and R. M. Lambrecht. 1991. Enriched Te-124 Targets for Production of I-123 and I-124. Journal of Nuclear Instrument Methods A303. PP. 115-118.
  21. Scholten, S. M. Qaim and G. Stocklin. 1989. Excitation functions of proton induced nuclear reactions on natural tellurium and enriched Te-123: Production of I-123 via the 123Te(p,n)123I process at a low-energy cyclotron. Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. Vol.40, No.2, PP.127-132.
  22. Bastian, H. H. Coenen and S. M. Qaim 2001. Excitation functions of Te-124(d,xn)I-124,125 reactions from threshold up to 14 MeV: comparative evaluation of nuclear routes for the production of I-124. Journal of Applied Radiation and Isotopes. Vol.55, No.3, PP.303–308.
  23. Hohn, F. M. Nortier, B. Scholten, T. N. Van Der Walt, H. H. Coenen and S. M. Qaim. 2001. Excitation Functions of 125-Te(P,XN) Reactions from Their Respective Thresholds Up to 100MeV with Special Reference to the Production of 124I. Journal of Applied Radiation and Isotopes. Vol.55, P.149--156.
  24. http://SRIM; www. SRIM2003.org.
  25. S. Krane. 1988. "Introductory Nuclear Physics. John Wiley and Sons, PP.378-379.
  26. Mahunka, L. Andó, P. Mikecz, A. N. Tcheltsov and A. Suvorov. 1996. Iodine-123 production at a small cyclotron for medical use. Journal of Radioanalytical and Nuclear Chemistry. Vol.213, No.2, PP. 135-142.
  27. Milton and K. Jacob. 1977. Radiochemistry of Iodine. Technical Information Center, Energy Research and Development Administer, United States of America, Springfield, Virginia 22161.
  28. (IAEA) International Atomic Energy Agency. 2009. "Cyclotron Produced Radionuclides Physical Characteristics and Production Methods". Vienna (2009) Technical reports series No. 468.
  29. S. Uddin, A. Hermanne, S. Sudár, M. N. Aslam, B. Scholten, H. H. Coenen and S. M. Qaima. 2011. Excitation functions of α-particle induced reactions on enriched 123Sb and natSb for production of I-124. Journal of Applied Radiation and Isotopes. Vol.69, No.4, PP.699–704.
Publication Details
  Published in : Volume 2 | Issue 6 | November-December 2016
  Date of Publication : 2016-12-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 106-111
Manuscript Number : IJSRST162548
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Iman Tarik Al-Alawy, Raghad S. Mohammed, "Direct Production of Radioiodine-123 from Tellurium with Lowest Level of Iodine Impurity-124", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 2, Issue 6 , pp.106-111, November-December-2016
URL : http://ijsrst.com/IJSRST162548