Antioxidant Potential of Roots of Clerodendrumserratum(Linn.)

Authors

  • Vaishali D. Murade  Padmashri Vikhe Patil College, Pravaranagar, Rahata, Ahmednagar, Gujarat, India
  • Sonali Dichayal  S. N. Arts, D. J. M. Commerce and B. N. Sarada Science College, Sangamner, Ahmednagar, Gujarat, India

Keywords:

Antioxidant, polyphenols, Clerodendrumserratum.

Abstract

The objective of this study was to determine the antioxidant capacity of polyphenols extracted from the roots of the Clerodendrumserratum plant. Extracts CSRC, CSRA and CSREA were found to have high percentage of total phenolic and flavonoid content and strong 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity. The results suggested that CSRC, CSREA and CSREAhas significant potential as a natural antioxidant to promote health and to reduce the risk of disease.

References

  1. Agrawal SK, Jat RK, Chhipa RC. Pharmacological evaluation of hepatoprotective activity of Clerodendrumserratum. International Journal of Pharmacology and Toxicology. 2013; 3(2): 67-70.
  2. Banerjee SK, Chakravarti RN, Sachdev KS, Vasavada SA. Constituents of rootbark of Clerodendrumserratum. Phytochemistry, 1969; 8: 515.
  3. Basma AA, Zakaria Z, Latha LY, Sasidharan B. Antioxidant activity and phytochemical screening on methanol extract of Euphorbia hirtaL.Asian Pacific Journal of Tropical Medicine,2011; 4: 386-390.
  4. Bhujbal SS, Kewatkar SM, Kumar D, Mudgade SC, Patil MJ.In-vivo and in-vitro anti-asthmatic studies of Clerodendrumserratum Linn.Pharmacologyonline, 2009a; 2: 745-752.
  5. Bhujbal SS, Kewatkar SMK, More LS, Patil MJ. Antioxidant effects of roots of Clerodendrumserratum Linn. Pharmacognosy Research, 2009b; 1: 294-298.
  6. Bhujbal SS, Nanda RK, Deoda RS, Kumar D, Kewatkar SM, More LS, Patil MJ.Structure elucidation of a flavonoid glycoside from the roots of Clerodendrumserratum (L.)Moon, Lamiaceae. BrazilianJournalofPharmacognosy, 2010d ; 20:1001-1002.
  7. Biapa N, Oben J, Ngogang J. Scavenging radical kinetic and antianaemic screening properties of some medicinal plants used in Cameroon. Int J Appl Res Nat Prod2011; 4: 29-35.
  8. Brown RH. Free radicals, programmed death and muscular dystrophy. Current Opinion in Neurology, 1995; 8: 373-378.
  9. Chinchali JF, Sanakal RD, Kaliwal BB. Evaluation of anticarcinogenic activity of Clerodendrumserratum leaf extract on liver and kidney of 7, 12-dimethylbenz[a]anthracene (DMBA) induced skin carcinogenesis in mice. European Journal of Experimental Biology, 2011; 1: 130-141.
  10. Fan,Ju-di,Long,Qing-de,Yang,J.,Luo,Xi-rong,Studies on the chemical constituents of Clerodendrumserratum (L.)Moon.Medical Journal of Chinese People’s Health, 2007; 19:423.
  11. Halliwell B. Antioxidants and human disease: a general introduction. Nutrition Review, 1997; 55: 44-49.
  12. Jorgensen LV, Madsen HL, Thomsen MK, Dragsted LO, Skibsted LH. Regulation of phenolic antioxidants from phenoxyl radicals: An ESR and electrochemical study of antioxidant hierarchy. Free Radical Research, 1999; 30: 207-220.
  13. Kalita P, Barman TK, Pal TK, Kalita R. Estimation of total flavonoid content and Antioxidant activities of methanolic whole plant extract of BiophytumSensitivum Linn. Journal of Drug delivery and Therapeutics, 2013; 3 (4): 33-37.
  14. Khatoon M., Islam E, Islam R, Rahman AB, KhurshidAlam AHM, Khondkar P, Rashid M, Parvin S. Estimation of total phenol and in vitro antioxidant activity of Albiziaprocera leaves. BMC Research Notes, 2013, 6, 121.
  15. Maddan R, Bansal G, Kumar S, Sharma A. Estimation of total phenols and flavonoids in extracts of Actaeaspicata roots and antioxidant activity studies. Indian Journal of Pharmaceutical Sciences, 2011: 73, 666-669.
  16. Manjunatha BK, Krishna V, Pullaiah T. Flora of Davangere District, Karnataka, India.Regency Publications, New Delhi, India.
  17. Mohamed AJ, Mohamed EAH, Abdalrahim FAA, Ameer OZ, Ismail Z, Ismail N, Shah AM, Abdulmajid MZA, Yam MF. Antioxidant, antiangiogenic and vasorelaxant activities of methanolic extract ofClerodendrumserratum (Spreng.) leaves. Journal of Medicinal Plants Research, 2012; 6: 348-360.
  18. Narayanan N, Thirugnanasambantham P, Viswanathan S, Vijayasekaran V, Sukumar E. Antinociceptive, anti-inflammatory and antipyretic effects of ethanol extract of Clerodendrumserratum roots in experimental animals. Journal of Ethnopharmacology, 1999; 65: 237-241.
  19. Patel JJ, Acharya SR, Acharya NS. Clerodendrumserratum(L.)Moon.-A review on traditional uses, phytochemistry and pharmacological activities. Journal of Ethnopharmacology, 2014; 154: 268-285.
  20. Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E1. Analytical Biochemistry, 1999: 269, 337-341.
  21. Raju R, Akoni JL, Subban R. Chemical constituents from Clerodendronserratum. Journal of Asian Natural Products Research, 2008; 10: 652-655.
  22. Rashid MT, Yadav AS, Bajaj A, Lone SA. An Assessment of antibacterial potency of aqueous leaf extract of Clerodendrumserratum Linn. against pathogenic bacterial strains. Indo American Journal of Pharmaceutical Research, 2013; 3(2): 1637-1644.
  23. Rekka E, Kourounakis PN. Effect of hydroxyethylrutosides and related compounds on lipid peroxidation and free radical scavenging activity of some structural aspects. Journal of Pharmacy and Pharmacology,1991; 43: 486-491.
  24. Rice-Evans C, Sampson J, Bramley PM, Holloway DE. Why do we expect carotenoids to be antioxidants in vivo.Free Radical Research 1997; 26: 381-398.
  25. Saeed N, Khan MR, Shabbir M.. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts TorilisleptophyllaL. BMC complementary and Alternative Medicine, 2012: 12, 221.
  26. Saha D, Talukdar A, Das T, Ghosh SK, Rahman H. Evaluation of analgesic activity of ethanolic extract of Clerodendrumserratum Linn.leaves in rats. International Research Journal of Pharmaceutical and applied sciences, 2012; 2(6): 33-37.
  27. Thalla, S, Tammu J, Pentela B, Thalla SR. Antiasthmatic activity of alcoholic extract of Clerodendrumserratum induced by ovalbumin. International Journal of Chemical and Pharmaceutical Sciences 2012; 3:83-85.
  28. Vidya SM, Krishna V, Manjunatha BK, Mankani KL, Ahmed M, Singh SDJ. Evaluation of hepatoprotective activity of Clerodendrumserratum L. Indian Journal of Experimental Biology, 2007; 45: 538-542.
  29. Vidya SM, Krishna V, Manjunatha BK, Rao RB. Antibacterial activity of Clerodendrumserratum L. Electronic Journal of Environmental, Agricultural and Food Chemistry, 2010; 9: 1059-1063.
  30. Wei XM, Zhu QX, Chen JC, Cheng DL. Two new iridoidglucosides from Clerodendrumserratum. Chemical Journal of Chinese Universities, 2000a; 21: 1675-1678.
  31. Yang H, Hou AJ, Mei SX, Peng LY, Sun HD. A new phenylpropanoid glycoside: Serratumoside A from Clerodendrumserratum. Chinese Chemical Letters, 2000a; 11(4): 323-326.
  32. Yang H, Jiang B, Na Z, Guo YP, Sun HD.Two new iridoidglucosides from Clerodendrumserratum. Chinese Chemical Letters, 2000c; 11: 231-234.
  33. Yang H, Mu Q, He YN, Sun HD. A new triterpenoidsaponin: Se-saponin A. Chinese Chemical Letters, 2000b; 11: 333-336.
  34. Zalke AS, Kulkarni AV, Shirode DS, Duraiswamy B. In-vivo anticancer activity of Clerodendrumserratum (L)Moon. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2010; 1: 89-98.

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Published

2017-12-31

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Section

Research Articles

How to Cite

[1]
Vaishali D. Murade, Sonali Dichayal, " Antioxidant Potential of Roots of Clerodendrumserratum(Linn.), International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 10, pp.01-05, November-December-2017.