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Synthesis of 5-Cyano Uracil Derivatives and Study of their Deamination Reaction

Authors(2) :-P. B. Aware, R. B. Toche

Facile synthesis of ureidopropenenitrileobtained by reaction of malenonitrile, orthoesterand substituted ureasat 100°C in good yields. The ureidopropenenitrile was cyclized to targeted 5-cyano Cytosine derivatives in presence of sodium ethoxide in ethanol with 60 -65% yields. The deamination of amino compound was studied to obtained uracil derivatives using ispentylnitrite.
P. B. Aware, R. B. Toche
Ureidopropenenitrile, Substituted Urea, 5-Cyano Cytosine, One Pot Three Component Reaction.
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Publication Details
  Published in : Volume 3 | Issue 10 | November-December 2017
  Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 46-49
Manuscript Number : IJSRST1731012
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
P. B. Aware, R. B. Toche, "Synthesis of 5-Cyano Uracil Derivatives and Study of their Deamination Reaction", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 10, pp.46-49, November-December-2017
URL : http://ijsrst.com/IJSRST1731012