Synthesis of 5-Cyano Uracil Derivatives and Study of their Deamination Reaction

Authors

  • P. B. Aware  CMCS College,Gangapur Road, Nashik, Maharashtra, India
  • R. B. Toche  Dadasaheb Bidkar Arts ,Science and Commerce College, Peth, Nashik, Maharashtra, India

Keywords:

Ureidopropenenitrile, Substituted Urea, 5-Cyano Cytosine, One Pot Three Component Reaction.

Abstract

Facile synthesis of ureidopropenenitrileobtained by reaction of malenonitrile, orthoesterand substituted ureasat 100°C in good yields. The ureidopropenenitrile was cyclized to targeted 5-cyano Cytosine derivatives in presence of sodium ethoxide in ethanol with 60 -65% yields. The deamination of amino compound was studied to obtained uracil derivatives using ispentylnitrite.

References

  1. Handbook of medicinal plants by S.K. Bhattacharjee IIIrd edn.
  2. Reviews on Indian Medicinal Plants. Vol III
  3. Wealth of India 1985
  4. Plants that Heal by J.C. Krishnan Vol. IPower Companies A Practical Example (Part I) . Database Systems Journal, IV(1), 37-45.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2017-12-31

Issue

Volume 3, Issue 10, November-December-2017

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
P. B. Aware, R. B. Toche, " Synthesis of 5-Cyano Uracil Derivatives and Study of their Deamination Reaction, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 10, pp.46-49, November-December-2017.