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Design New Pyrano Quinoline Derivatives and Study of their Anti-Microbial Activity

Authors(2) :-Rahul Watpade, Raghunath B. Toche

4,5,7-Trichloro-3-(2-chloroethyl)-2-methylbenzo[h][1,6]naphthyridine 1 was selectively converted to 5-iminoether 5 by the reaction with sodium alkoxy in corresponding alcohol and to 2-methylbenzo[h][1,6]naphthyridin-5(6H)-one 2 by acetic acid reflux. The reaction selectively occurs at C5-position of the benzo[h][1,6]naphthyridine. Further, 2-methylbenzo[h][1,6] naphthayridin-5(6H)-one 2 furnish O and N alkylation products 3 and 4 with bromoethylacetate respectively. The reaction of 2 with bromoacetamide yield O-acetanilide i.e. 2-(4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diaza-cyclopenta[a]phenanthren-7-ylsulfanyl)-N-phenyl acetamide 6 in major amount.
Rahul Watpade, Raghunath B. Toche
Pyranoqunoline Reactions, benzo[h][1,6]Naphthyridines, Antimicrobial Activity
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Publication Details
  Published in : Volume 3 | Issue 10 | November-December 2017
  Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 90-95
Manuscript Number : IJSRST1731021
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Rahul Watpade, Raghunath B. Toche, "Design New Pyrano Quinoline Derivatives and Study of their Anti-Microbial Activity", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 10, pp.90-95, November-December-2017
URL : http://ijsrst.com/IJSRST1731021