Design New Pyrano Quinoline Derivatives and Study of their Anti-Microbial Activity

Authors

  • Rahul Watpade  Organic Chemistry Research Centre, Department of Chemistry, K. R. T. Arts, B. H.Commerce and A. M. Science College, Gangapur Road, Nashik, Maharashtra, India
  • Raghunath B. Toche  Organic Chemistry Research Centre, Department of Chemistry, K. R. T. Arts, B. H.Commerce and A. M. Science College, Gangapur Road, Nashik, Maharashtra, India

Keywords:

Pyranoqunoline Reactions, benzo[h][1,6]Naphthyridines, Antimicrobial Activity

Abstract

4,5,7-Trichloro-3-(2-chloroethyl)-2-methylbenzo[h][1,6]naphthyridine 1 was selectively converted to 5-iminoether 5 by the reaction with sodium alkoxy in corresponding alcohol and to 2-methylbenzo[h][1,6]naphthyridin-5(6H)-one 2 by acetic acid reflux. The reaction selectively occurs at C5-position of the benzo[h][1,6]naphthyridine. Further, 2-methylbenzo[h][1,6] naphthayridin-5(6H)-one 2 furnish O and N alkylation products 3 and 4 with bromoethylacetate respectively. The reaction of 2 with bromoacetamide yield O-acetanilide i.e. 2-(4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diaza-cyclopenta[a]phenanthren-7-ylsulfanyl)-N-phenyl acetamide 6 in major amount.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

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Volume 3, Issue 10, November-December-2017

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Research Articles

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How to Cite

[1]
Rahul Watpade, Raghunath B. Toche, " Design New Pyrano Quinoline Derivatives and Study of their Anti-Microbial Activity, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 10, pp.90-95, November-December-2017.