Translocation of Cyclophosphamide by Using Multi-Walled Carbon Nanotubes Into Mammalian Cancer Cells

Authors

  • P. S. Uttekar  P. E. Society’s, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India
  • V. V. Chopade  P. E. Society’s, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India

Keywords:

Multiwall Carbon nanotubes (MWCNTs), cyclophosphamide, Functionalization of MWCNTs, Translocation.

Abstract

The aim of the present work was to prepare cyclophosphamide loaded MWCNTs for target drug delivery of Cyclophosphamide (CP), an Anti-Cancer drug. Experimental designing was done by using the Ultrasonic probe sonicator, PCI Analytics DP-120 under continuous stirring. Translocation of cyclophosphamide was done on functionalized MWCNTs. Functionalization of MWCNTs was done by Acid Purification of pure MWCNTs & conjugation of FA-EDA with oxidized MWCNTs.The loaded MWCNTs were characterized for various parameters including the MTT assay,DSC,SEM,FTIR, Zeta Potential,NMR,Particle Size Analysis, XRD, Stability Study & poly dispersive Index.it is worth that the cyclophosphamide loaded MWCNTs showed better targeting action.

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International Journal of Scientific Research in Science and Technology

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2017-12-31

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Volume 3, Issue 10, November-December-2017

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Research Articles

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[1]
P. S. Uttekar, V. V. Chopade, " Translocation of Cyclophosphamide by Using Multi-Walled Carbon Nanotubes Into Mammalian Cancer Cells, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 10, pp.121-136, November-December-2017.