Transition metal (II) Complexes with Schiff base of 1, 2, 4-Triazole-4-amine & 4-dimethylamino-benzaldehyde and their Antimicrobial Activity

Authors

  • Bharati K.T  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India
  • Gujarathi D. B  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India
  • Tryambake P. T  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India
  • Hase G. J  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India
  • Gagare N. B  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India
  • Bhor J. B  S. N. Arts, D. J. M. Commerce & B.N.S Science College, Sangamner, Ahmednagar, Maharashtra, India

Keywords:

1, 2, 4- triazole-4-amine, Schiff base and Co-ordination compounds.

Abstract

This study summarizes the synthesis of new Schiff bases derivatives of 1, 2, 4-triazole-4-amine with 4-dimethylamino-benzaldehyde. The co-ordination compounds of transition metal ions like Cu (II) and Zn (II) with the Schiff bases were synthesized and characterized by UV-Visible Spectroscopy, Infra-Red Spectroscopy, NMR, Elemental Analysis and Magnetic Susceptibility Measurement. These co-ordination compounds show moderate biological activity against bacterial strains.

References

  1. Neslihan, D.; Ahmet, D.; Sengul, A and Sancak, K; "Synthesis and antimicrobial activities of some new 1, 2, 4-triazole derivatives", Eur.J.Med. Chem. (2004), 39:793-804.
  2. Neslihan, D.; Ahmet, D.; Sengul, A and Elif. C; "Synthesis and antimicrobial activities of some new [1, 2, 4] triazole [3,4b] [1, 3, 4] thiadiazines" ARKIVOC (i). (2005), 75-91.
  3. Aiyalu, R. and Kalasalingam A.R, "Synthesis of some novel triazole derivatives as anti-nociceptive and anti-inflammatory agents", 2009, 59: 355-364.
  4. T. Mahmud, "Synthesis characterization and study of antibacterial activity of Enaminones complexes with Zinc and Iron", Arab. J. Chem; 2010, 3(4), 219-224.
  5. Suresh Kumar G. V., Rajendraprasad Y, Malikarjuna B. P.? Chandrasekhar S. M. and Kistayya C, "Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1, 2, 4-triazole and 1, 3, 4-oxadiazoles as potential antimicrobial and antitubercular agents",? Eur. J. Med Chem., 2010, 45, 2063-74.
  6. Chohan Z. H. and Supran C. T., "In-vitro antibacterial and cytotoxic activity of Cobalt (II), Nickel (II) and Zinc (II) complexes of the antibiotic drug Cephalothin (Keflin)",J. Enz. Inhib. Med. Chem., 2005, 20, 463-468.
  7. Singh K, Kumar Y, Pundir R. K., "Synthesis and characterization of biologically active organosilicon (IV) complexes with Schiff bases derived from o-aminothiophenol",? Synth. React. Inorg. Met. Org. Chem., 2010, 40, 836-842.
  8. Altundas A, Nursen S, Colak N, Ogutchi H., "Synthesis and biological activity of new cycloalkylthiophene Schiff bases and their Cr (III) and Zn (II) complexes", Med. Chem. Res., 2010, 19, 576-588.
  9. Nurhan G.; Mevlut S.; Elif C.; Ali S.; and Neslishan D, "Synthesis and antimicrobial activity of some new 1, 2, 4-triazole derivatives," Turk. J. Chem., 2007, 31, 335-348.
  10. Akbar Mobinkhaledi, Naser Foroughifar, Mansooreh Khanpour and Sattar Ebrahimi, "Synthesis of some novel Schiff bases containing 1, 2, 4-triazole ring", Eur. J. of Chem., 2010, 1(1), 33-36.
  11. Katarzyna Wajda-Hermanowicz, Damian Pieni??czak, Aleksandra Zatajska, Robert Wr?bel, Krzysztof Drabent and Zbigniew Ciunik; "A Study on the Condensation Reaction of 4-Amino-3,5-dimethyl-1,2,4-triazole with Benzaldehydes: Structure and Spectroscopic Properties of Some New Stable Hemiaminals", Molecules, 2015, 20(9), 17109-17131.
  12. Bharati K.T; Gujarathi D. B; Tryambake P. T; Hase G. J; Gaikwad R. K. and Khatal M. B, "Preparation of Schiff base of 1, 2, 4-Triazole-4-amine with 3-nitrobenzaldehyde, its Complexation with Cu (II) and Zn (II) and Antimicrobial Activity of Complexes", Der Chemica Sinica, 8(2), 233-228, 2017.
  13. Dr. M. K. Lalitha, "Manual of antimicrobial susceptibility testing", Indian Journal of Medical Microbiologist, Christian Medical College and Hospital, Vellore, India.
  14. Song L, Xie Y, Wang H, "Synthesis and antibacterial activity of benzimidazole Schiff base," 2000, 10, 92-94.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2017-12-31

Issue

Volume 3, Issue 10, November-December-2017

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Bharati K.T, Gujarathi D. B, Tryambake P. T, Hase G. J, Gagare N. B, Bhor J. B, " Transition metal (II) Complexes with Schiff base of 1, 2, 4-Triazole-4-amine & 4-dimethylamino-benzaldehyde and their Antimicrobial Activity , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 10, pp.147-152, November-December-2017.