Structural Annotation and Homology Modeling of Protein Kinase 6(PfPK6) from Plasmodium Falciparum

Authors

  • Yogesh N. Joshi  Department of PG studies and Research in Bioinformatics, Walchand Centre for Biotechnology, Walchand College of Arts & Science, Solapur, Maharashtra, India
  • Vinod P. S.  Department of PG studies and Research in Bioinformatics, Walchand Centre for Biotechnology, Walchand College of Arts & Science, Solapur, Maharashtra, India
  • Vyankatramna Yemul  Department of PG studies and Research in Bioinformatics, Walchand Centre for Biotechnology, Walchand College of Arts & Science, Solapur, Maharashtra, India

Keywords:

Malaria, Plasmodium falciparum, PfPK6, In silico , cyclin-dependent kinase etc.

Abstract

Malaria is a major public health burden in the developing world. Plasmodium falciparum enters in blood stream and replicates in S-phase of cell cycle and releases merozoites. PfPK6, a putative homologue of p34cdc cyclin-dependent kinase (CDK) required for entry into both S-phase and mitosis. Our work suggests that PfPK6 protein can acts as target for the inhibition of Plasmodium falciparum activity in Malaria disease. The present investigation includes retrieval of amino acid information and sequence analysis of PfPK6 from major protein sequence database and tools. The Physiochemical parameters like amino acid propensity, molecular weight, isoelectric point, aliphatic index, hydropathicity were determined. The secondary structure of PfPK6 was predicted using SOPMA secondary structure method. The 3D structure was predicted using SWISS-MODEL server and model was further validated using PROCHECK analysis tool. The function of PfPK6 was identified by Pfam domain database. In silico structural characterization and homology modeling of PfPK6 can put insight into development of new antimalarial drugs by structure based drug designing.

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International Journal of Scientific Research in Science and Technology

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Published

2017-02-28

Issue

Volume 3, Issue 1, January-February-2017

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Yogesh N. Joshi, Vinod P. S., Vyankatramna Yemul, " Structural Annotation and Homology Modeling of Protein Kinase 6(PfPK6) from Plasmodium Falciparum, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 1, pp.248-251 , January-February-2017.