Synthesis and Characterizations of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents

Authors(2) :-Shital N. Chadotra, Dr. B. B. Baldaniya

The aim of this study was to synthesize several pyrimidine derivatives. Pyrimidine nucleus was synthesized by Biginelli reaction in past. (1) At first stage reaction the pyrimidine derivative synthesized by reaction between EAA (ethylacetoacetate), substituted benzaldehyde, and thiourea. (2) At second stage reaction give excellent yield of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (1-13) synthesized by using first reaction derivative, chloro acetic acid, sodium acetate, acetic anhydride, glacial acetic acid with various substituted benzaldehyde. They are characterized by elemental analyses like IR spectra, NMR spectra and GCMS. The products have been tested for their antibacterial and antifungal activity against gram (+) positive and gram (-) negative bacteria.

Authors and Affiliations

Shital N. Chadotra
Department of Chemistry, M. G. Science institute, Navarangpura, Ahmedabad, Gujarat, India
Dr. B. B. Baldaniya
Department of Chemistry, M. G. Science institute, Navarangpura, Ahmedabad, Gujarat, India

2,3,8,8a-tetrahydro, Pyrimidine, Biginelli reaction, Antibacterial activity, Antifungal activity.

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Publication Details

Published in : Volume 3 | Issue 3 | March-April 2017
Date of Publication : 2017-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 366-370
Manuscript Number : IJSRST1733123
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Shital N. Chadotra, Dr. B. B. Baldaniya, " Synthesis and Characterizations of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents, International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 3, pp.366-370, March-April-2017. Available at doi : 10.32628/IJSRST1733123
Journal URL : http://ijsrst.com/IJSRST1733123

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