Synthesis and Characterizations of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents

Authors

  • Shital N. Chadotra  Department of Chemistry, M. G. Science institute, Navarangpura, Ahmedabad, Gujarat, India
  • Dr. B. B. Baldaniya  Department of Chemistry, M. G. Science institute, Navarangpura, Ahmedabad, Gujarat, India

Keywords:

2,3,8,8a-tetrahydro, Pyrimidine, Biginelli reaction, Antibacterial activity, Antifungal activity.

Abstract

The aim of this study was to synthesize several pyrimidine derivatives. Pyrimidine nucleus was synthesized by Biginelli reaction in past. (1) At first stage reaction the pyrimidine derivative synthesized by reaction between EAA (ethylacetoacetate), substituted benzaldehyde, and thiourea. (2) At second stage reaction give excellent yield of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (1-13) synthesized by using first reaction derivative, chloro acetic acid, sodium acetate, acetic anhydride, glacial acetic acid with various substituted benzaldehyde. They are characterized by elemental analyses like IR spectra, NMR spectra and GCMS. The products have been tested for their antibacterial and antifungal activity against gram (+) positive and gram (-) negative bacteria.

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International Journal of Scientific Research in Science and Technology

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Published

2017-04-30

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Volume 3, Issue 3, March-April-2017

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Research Articles

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[1]
Shital N. Chadotra, Dr. B. B. Baldaniya, " Synthesis and Characterizations of ethyl(2Z)-2-(Aryl)-5-(4-hydroxy-3-methoxyphenyl)-7-methyl-3-oxo-2,3,8,8a-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives as Biological and Antifungal Active Agents, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 3, pp.366-370, March-April-2017.