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Synthesis, Characterizations and Antimicrobial activity of Oxazolidinone and Imidazolidinone Derivatives

Authors(2) :-Hitendra N Patel , Dr. B.B.Baldaniya

Glycine (1) was allowed to react with substituted benzoyl chloride (2) to give substituted hippuric acid(3). Different aldehydes were treated with compound(3a-b)to get 1,3-oxazole-5-ones derivative(4a-j, 7a-j). These oxazolinones were treated with various aromatic amines to get various imidazol-5-ones derivatives (5a-j, 6a-j, 8a-j, 9a-j). Compounds characterized by elemental analyses like IR spectra, NMR spectra and GCMS. The products have been tested for their antifungal and antibacterial activity against gram (+) ve and gram (-) ve bacteria.
Hitendra N Patel , Dr. B.B.Baldaniya
Oxazolinone, Imidazol-5-Ones, Antibacterial Activity, Antifungal Activity.
  1. A.K.Mukherjee, Heterocycles 1987, 26, 1077-1097.
  2. J.S.Fisk, R.A.Mosey, J.J.Tepe, Chem. Soc. Rev. 2007, 36, 1432-1440.
  3. K.M.Khan, U.R.Mughal, M.T.H. khan, Z. Ullah, S.Perveen., M.I.Choudhary, Bioorg, Med. Chem. 2006, 14, 6027-6023.
  4. K.M.Khan, U.R.Mughal, M. A. Lodhi, M.I.Choudhary, Lett. Drug Design Discovery, 2008, 5, 52-56.
  5. M. Kitzawa, R. Higuchi, M. Takahashi, T. Wada, H. Sasabe, J. Phys. Chem, 1995, 99, 14784-14792.
  6. K. Ertekin, S.Alp, C. Karapire, B. Yenigul, E. Henden, S. leli, J. Photochem.Photobiol. A 2000, 137, 155-161.
  7. Beceiro, A., Tomás, M., and Bou, G., Clinical Microbiology Reviews, Vol. 26(2), pp. 185-230, 2013.
  8. Verma M, Chaturvedi AK, Chaudhari A, Parmar SS, T Pharma Sci, 1974; 63, 1740-1744.
  9. Naithani PK, Srivastava VK, Barthwal JP, Saxena AK, Gupta TK, Indian J Chem 1989;28:990–992.
  10.  Harfenist M, Soroko FE, McKenzie GM. J Med Chem; 1978;21:405–409.
  11. Magd-El-Din AA, Abd-El-All AS, Roaiah HMF, El-Baroudy, MMS. J Am Sci;2010;6:251–256.
    1. Desai NC, Bhavsar AM, Baldaniya BB. Indian J Pharm Sci, 2009;71:90–94.
    2. Joshi H, Upadhyay P, Karia D, Baxi AJ. Eur J Med Chem, 2003;38:837–840.
    3. N.S. Hari Narayana Moorthy, Vipin Saxena, C. Karthikeyan and Piyush Trivedi, Journal of Enzyme Inhibition and Medicinal Chemistry, 2012; 27(2):201-207.
    4. Lacroix, Guy;Pegnier Raymond; Pepin Regis; Bascou, Jean Philippe, Perer; joseph;schmitz;christian U.S. US B, 002, 016 (1999), Chemical Abstsrct 132, 356998e.
    5. Saravanan S., Selvan P. S., Gopal N., Gupta J. K. and De B.; Arch. Pharm.Chem. Life Sci., 338, 2005, 488.
    6. Reena Rathore, Pramilla Sah; Journal of Chemical, Biological and Physical Sciences; 5, 2, 2015; 1152-1159.
    7. John Coates, Interpretation of Infrared Spectra, A Practical Approch; Encyclopedia of Analytical Chemistry; R.A.Meyers (Ed.), pp. 10818-10837, John wiley and Sons Ltd, Chichester, 2000.
    8. Gregory et al, NMR Chemical Shift of Trace Impurities; Organomettalics; 2010, 29, 2176-2179.
    9. National Committee for Clinical Laboratory Standard. Reference Method for broth dilution antifungal susceptibility testing of yeasts; Approved standrd M27A2; 2002, NCCLS, Wayne, PA.
Publication Details
  Published in : Volume 3 | Issue 3 | March-April 2017
  Date of Publication : 2017-04-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 211-216
Manuscript Number : IJSRST173340
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Hitendra N Patel , Dr. B.B.Baldaniya, "Synthesis, Characterizations and Antimicrobial activity of Oxazolidinone and Imidazolidinone Derivatives", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 3, pp.211-216 , March-April-2017
URL : http://ijsrst.com/IJSRST173340