Diet, Gut Microbiota and Its Association with Colon Cancer

Authors

  • Sana Ashraf  Institute of Industrial Biotechnology, GC University, Lahore, Pakistan
  • Zannara Mustafa  Institute of Industrial Biotechnology, GC University, Lahore, Pakistan
  • Syeda Fareeha Tauheed  Institute of Industrial Biotechnology, GC University, Lahore, Pakistan
  • Sikander Ali  Institute of Industrial Biotechnology, GC University, Lahore, Pakistan

Keywords:

Acetone, Anti-Carcinogens, Butyrate, Colorectal Cancer, Fermentation, Glutathione S Transferase (Gsts), Probiotics, Propionate, Short Chain Fatty Acids.

Abstract

Probiotics and prebiotics are very necessary for the intestinal health of human. Probiotics may be naturally present in the individual’s colon or it its growth may be enhanced by administrating adequate amount of prebiotics which favors their growth. Many factors like type of diet, quantity, its transit time and its pH determine the type, growth and efficiency of colonic bacteria. Probiotic ferment the dietary fibers and produces significant amount of many metabolites. Among these metabolites production of short chain fatty acids are very important as they plays many vital role in prevention of many diseases but recent research shows that they are anti-carcinogens and prevent colonic cells to mutate into cancerous cells. So dietary fibers and their corresponding bacteria save us from colorectal cancer. GSTs are important enzymes that prove helpful to increase immunity and act as chemoprevention in early stages of cancer.

References

  1. Joint, F. A. O. "WHO working group report on drafting guidelines for the evaluation of probiotics in food." London, Ontario, Canada 30 (2002).
  2. Gibson, G. R., and M. B,? Roberfroid. 1995. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition, 125(6): 1401.
  3. Liong, Min-Tze. "Probiotics: a critical review of their potential role as antihypertensives, immune modulators, hypocholesterolemics, and perimenopausal treatments." Nutrition reviews 65.7 (2007): 316-328.
  4. Salminen, S., et al. "Functional food science and gastrointestinal physiology and function." British Journal of Nutrition 80.S1 (1998): S147-S171.
  5. Sant, Milena, et al. "Comparisons of colon?cancer survival among european countries: The eurocare study." International journal of cancer 63.1 (1995): 43-48.
  6. Allison, C., and G. T. Macfarlane. "Effect of nitrate on methane production and fermentation by slurries of human faecal bacteria." Microbiology 134.6 (1988): 1397-1405.
  7. Chen, Hui-Min, et al. "Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma." The American journal of clinical nutrition 97.5 (2013): 1044-1052.
  8. Bernalier, Annick, Jo?l Dore, and Michelle Durand. "Biochemistry of fermentation." Colonic microbiota, nutrition and health. Springer Netherlands, (1999): 37-53.
  9. Flint, Harry J., et al. "The role of the gut microbiota in nutrition and health." Nature reviews. Gastroenterology & hepatology 9.10 (2012): 577.
  10. Ebert, Miriam Nannette, et al. "Butyrate induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxy-2-nonenal." Nutrition and cancer 41.1-2 (2001): 156-164.
  11. Walker, Alan W., et al. "Dominant and diet-responsive groups of bacteria within the human colonic microbiota." The ISME journal 5.2 (2011): 220.
  12. Flint, Harry J., et al. "Microbial degradation of complex carbohydrates in the gut." Gut microbes 3.4 (2012): 289-306.
  13. Salonen, Anne, et al. "Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men." The ISME journal 8.11 (2014): 2218-2230.
  14. Severance, Emily G., Robert H. Yolken, and William W. Eaton. "Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling." Schizophrenia research (2014).
  15. Toma?s-Barbera?n, Francisco A., and Yoshinori Mine. "A key to understanding the effects of food bioactives in health, gut microbiota." (2013): 9755-9757.
  16. Le Chatelier, Emmanuelle, et al. "Richness of human gut microbiome correlates with metabolic markers." Nature 500.7464 (2013): 541-546.
  17. Aune, Dagfinn, et al. "Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies." Bmj 343 (2011): d6617.
  18. Ou, Junhai, et al. "Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans." The American journal of clinical nutrition 98.1 (2013): 111-120.
  19. Marcobal, A., et al. "A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice." The ISME journal 7.10 (2013): 1933.
  20. Sieber, Jessica R., Michael J. McInerney, and Robert P. Gunsalus. "Genomic insights into syntrophy: the paradigm for anaerobic metabolic cooperation." Annual review of microbiology 66 (2012): 429-452.
  21. Carbonero, Franck, et al. "Microbial pathways in colonic sulfur metabolism and links with health and disease." Frontiers in physiology 3 (2012): 448.
  22. Hamer, Henrike M., et al. "Functional analysis of colonic bacterial metabolism: relevant to health?." American Journal of Physiology-Gastrointestinal and Liver Physiology 302.1 (2012): G1-G9.
  23. Macfarlane, G. T., H. Steed, and S. Macfarlane. "Bacterial metabolism and health?related effects of galacto?oligosaccharides and other prebiotics." Journal of applied microbiology 104.2 (2008): 305-344.
  24. Gibson, Glenn R., and George T. Macfarlane. Human colonic bacteria: role in nutrition, physiology and pathology. CRC Press, 1995.
  25. Cummings, JH1, et al. "Short chain fatty acids in human large intestine, portal, hepatic and venous blood." Gut 28.10 (1987): 1221-1227.
  26. Miller, Terry L., and Meyer J. Wolin. "Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora." Applied and Environmental Microbiology 62.5 (1996): 1589-1592.
  27. Arumugam, Manimozhiyan, et al. "Enterotypes of the human gut microbiome." nature 473.7346 (2011): 174.
  28. Hosseini, Elham, et al. "Propionate as a health-promoting microbial metabolite in the human gut." Nutrition Reviews 69.5 (2011): 245-258.
  29. Cummings, J. H. "Diet and transit through the gut." J Plant Foods 3 (1978): 83-95.
  30. Cummings, J. H., and G. T. Macfarlane. "The control and consequences of bacterial fermentation in the human colon." Journal of Applied Bacteriology 70.6 (1991): 443-459.
  1. Macfarlane, G. T., and Glenn R. Gibson. "Metabolic activities of the normal colonic flora." Human Health. Springer London, 1994. 17-52.
  2. Gibson, G. R., S. Macfarlane, and G. T. Macfarlane. "Metabolic interactions involving sulphate-reducing and methanogenic bacteria in the human large intestine." FEMS Microbiology Ecology 12.2 (1993): 117-125.
  3. Macfarlane, G. T., Glenn Gibson, and S. Macfarlane. "Short chain fatty acid and lactate production by human intestinal bacteria grown in batch and continuous culture." (1994): 44-60.
  4. Fleming, Sharon E., and H. Kobayashi. "The Source of Dietary Fiber Influences?Short-Chain Fatty Acid Production and Concentrations in the Large Bowel." CRC Handbook of Dietary Fiber in Human Nutrition, Third Edition. CRC Press, 2001. 287-315.
  5. Macy, Joan M., Lars G. Ljungdahl, and Gerhard Gottschalk. "Pathway of succinate and propionate formation in Bacteroides fragilis." Journal of Bacteriology 134.1 (1978): 84-91.
  6. Duncan, Sylvia H., et al. "Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces." Applied and environmental microbiology 73.4 (2007): 1073-1078.
  7. Duncan, Sylvia H., et al. "Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces." Applied and environmental microbiology 73.4 (2007): 1073-1078.
  8. Macfarlane, Sandra, and George T. Macfarlane. "Regulation of short-chain fatty acid production." Proceedings of the Nutrition Society 62.01 (2003): 67-72.
  9. Sengupta, Shomik, Jane G. Muir, and Peter R. Gibson. "Does butyrate protect from colorectal cancer?." Journal of gastroenterology and hepatology 21.1 (2006): 209-218.
  10. Scheppach, Wolfgang, and Frank Weiler. "The butyrate story: old wine in new bottles?." Current Opinion in Clinical Nutrition & Metabolic Care 7.5 (2004): 563-567.
  11. Hayes, John D., and David J. Pulford. "The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II." Critical reviews in biochemistry and molecular biology 30.6 (1995): 521-600.
  12. Johnson, I. T., G. Williamson, and S. R. R. Musk. "Anticarcinogenic factors in plant foods: a new class of nutrients?." Nutrition Research Reviews 7.01 (1994): 175-204.
  13. Nava, Gerardo M., et al. "Abundance and diversity of mucosa-associated hydrogenotrophic microbes in the healthy human colon." The ISME journal 6.1 (2012): 57-70.

International Journal of Scientific Research in Science and Technology

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Published

2017-06-30

Issue

Volume 3, Issue 4, May-June-2017

Section

Research Articles

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How to Cite

[1]
Sana Ashraf, Zannara Mustafa, Syeda Fareeha Tauheed, Sikander Ali, " Diet, Gut Microbiota and Its Association with Colon Cancer, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 4, pp.436-443, May-June-2017.