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Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers

Authors(4) :-R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton

Electrospun nanofibers can be used as carriers in various drug delivery applications for controlled delivery of several bioactive molecules. In this study, effect of flow rate on fiber morphology and naringin release of naringin loaded polycaprolactone nanofibers was evaluated. The scanning electron microscopy results showed increased average fiber diameters in naringin loaded polycaprolactone nanofibers compared to polycaprolactone nanofibers as well as with increasing flow rates. Further, Fourier transform infrared spectroscopy analysis implies that encapsulated naringin was not chemically changed during the encapsulation process. Furthermore, increased cumulative naringin release profiles were observed with increasing flow rates for 12 days. These results suggest that, naringin release rate can be manipulated by varying the flow rates which could help to obtain desired naringin release rate for various therapeutic applications.
R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton
Electrospinning, Flow Rate Effect, Polycaprolactone Nanofibers, Naringin, Drug Delivery
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Publication Details
  Published in : Volume 3 | Issue 7 | September-October 2017
  Date of Publication : 2017-10-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 05-08
Manuscript Number : IJSRST17372
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton, "Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 7, pp.05-08 , September-October-2017
URL : http://ijsrst.com/IJSRST17372