Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers

Authors

  • R. Ranjith  P.G. and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India
  • S. Balraj  P.G. and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India
  • J. Ganesh  P.G. and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India
  • M.C. John Milton  P.G. and Research Department of Advanced Zoology and Biotechnology, Loyola College, Chennai, Tamil Nadu, India

Keywords:

Electrospinning, Flow Rate Effect, Polycaprolactone Nanofibers, Naringin, Drug Delivery

Abstract

Electrospun nanofibers can be used as carriers in various drug delivery applications for controlled delivery of several bioactive molecules. In this study, effect of flow rate on fiber morphology and naringin release of naringin loaded polycaprolactone nanofibers was evaluated. The scanning electron microscopy results showed increased average fiber diameters in naringin loaded polycaprolactone nanofibers compared to polycaprolactone nanofibers as well as with increasing flow rates. Further, Fourier transform infrared spectroscopy analysis implies that encapsulated naringin was not chemically changed during the encapsulation process. Furthermore, increased cumulative naringin release profiles were observed with increasing flow rates for 12 days. These results suggest that, naringin release rate can be manipulated by varying the flow rates which could help to obtain desired naringin release rate for various therapeutic applications.

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International Journal of Scientific Research in Science and Technology

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Published

2017-10-31

Issue

Volume 3, Issue 7, September-October-2017

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Research Articles

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How to Cite

[1]
R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton, " Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 7, pp.05-08 , September-October-2017.