Home > Archives > IJSRST17372 IJSRST-Library

Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers

Authors(4) :-R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton

Electrospun nanofibers can be used as carriers in various drug delivery applications for controlled delivery of several bioactive molecules. In this study, effect of flow rate on fiber morphology and naringin release of naringin loaded polycaprolactone nanofibers was evaluated. The scanning electron microscopy results showed increased average fiber diameters in naringin loaded polycaprolactone nanofibers compared to polycaprolactone nanofibers as well as with increasing flow rates. Further, Fourier transform infrared spectroscopy analysis implies that encapsulated naringin was not chemically changed during the encapsulation process. Furthermore, increased cumulative naringin release profiles were observed with increasing flow rates for 12 days. These results suggest that, naringin release rate can be manipulated by varying the flow rates which could help to obtain desired naringin release rate for various therapeutic applications.
R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton
Electrospinning, Flow Rate Effect, Polycaprolactone Nanofibers, Naringin, Drug Delivery
  1. Y. J. Kim, M.R. Park, M.S. Kim, O.H. Kwon, Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells, Mater. Chem. Phys. 133 (2012) 674-680.
  2. P. Karuppuswamy, J. Reddy Venugopal, B. Navaneethan, A. Luwang Laiva, S. Ramakrishna, Polycaprolactone nanofibers for the controlled release of tetracycline hydrochloride, Mater. Lett. 141 (2015) 180-186.
  3. C. Berkland, M. King, A. Cox, K. (Kevin) Kim, D.W. Pack, Precise control of PLG microsphere size provides enhanced control of drug release rate, J. Control. Release. 82 (2002) 137-147.
  4. K. Kim, Y.K. Luu, C. Chang, D. Fang, B.S. Hsiao, B. Chu, M. Hadjiargyrou, Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds, J. Control. Release. 98 (2004) 47-56.
  5. W. Cui, X. Li, X. Zhu, G. Yu, S. Zhou, J. Weng, Investigation of Drug Release and Matrix Degradation of Electrospun Poly(dl-lactide) Fibers with Paracetanol Inoculation, Biomacromolecules. 7 (2006) 1623-1629.
  6. A. Haider, S. Haider, I.-K. Kang, A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology, Arab. J. Chem. (2015).
  7. S. Zargham, S. Bazgir, A. Tavakoli, A.S. Rashidi, R. Damerchely, The Effect of Flow Rate on Morphology and Deposition Area of Electrospun Nylon 6 Nanofiber, J. Eng. Fiber. Fabr. 7 (2012) 42-49.
  8. D. Mondal, M. Griffith, S.S. Venkatraman, Polycaprolactone-based biomaterials for tissue engineering and drug delivery: Current scenario and challenges, Int. J. Polym. Mater. Polym. Biomater. 65 (2016) 255-265.
  9. M. Adil, A. Visnagri, V.S. Kumar, A.D. Kandhare, P. Ghosh, S.L. Bodhankar, Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats, Pharmacologia. 5 (2014) e234.
  10. Peng-Zhang, K. Dai, S. Yan, W. Yan, Chao-Zhang, D. Chen, Bo-Xu, Z. Xu, Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell, Eur. J. Pharmacol. 607 (2009) 1-5.
  11. Y. Ji, L. Wang, D.C. Watts, H. Qiu, T. You, F. Deng, X. Wu, Controlled-release naringin nanoscaffold for osteoporotic bone healing, Dent. Mater. 30 (2014) 1263-1273.
  12. R. Ranjith, S. Balraj, J. Ganesh, M.C.J. Milton, Electrospun Polycaprolactone Nanofibers for Sustained Release of Naringin, Int. J. Sci. Res. Sci. Technol. 3 (2017) 235-238.
  13. T. Amna, N.A.M. Barakat, M.S. Hassan, M.-S. Khil, H.Y. Kim, Camptothecin loaded poly(?-caprolactone)nanofibers via one-step electrospinning and their cytotoxicity impact, Colloids Surfaces A Physicochem. Eng. Asp. 431 (2013) 1-8.
  14. M. Ranjbar-Mohammadi, S.H. Bahrami, Electrospun curcumin loaded poly(?-caprolactone)/gum tragacanth nanofibers for biomedical application, Int. J. Biol. Macromol. 84 (2016) 448-456.
  15. N. Sahu, D. Soni, B. Chandrashekhar, D.B. Satpute, S. Saravanadevi, B.K. Sarangi, R.A. Pandey, Synthesis of silver nanoparticles using flavonoids: hesperidin, naringin and diosmin, and their antibacterial effects and cytotoxicity, Int. Nano Lett. 6 (2016) 173-181.
  16. J. B.E. Mendes, M.K. Riekes, V.M. de Oliveira, M.D. Michel, H.K. Stulzer, N.M. Khalil, S.F. Zawadzki, R.M. Mainardes, P.V. Farago, PHBV/PCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes, Sci. World J. 2012 (2012) 542937.
  17. D. G. Yu, L.-M. Zhu, K. White, C. Branford-White, Electrospun nanofiber-based drug delivery systems, Health (Irvine. Calif). 1 (2009) 67-75.
  18. A. Repanas, S. Andriopoulou, B. Glasmacher, The significance of electrospinning as a method to create fibrous scaffolds for biomedical engineering and drug delivery applications, J. Drug Deliv. Sci. Technol. 31 (2016) 137-146.
  19. P.T. and U.R. and P. Supaphol, Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs, Nanotechnology. 17 (2006) 2317.
Publication Details
  Published in : Volume 3 | Issue 7 | September-October 2017
  Date of Publication : 2017-10-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 05-08
Manuscript Number : IJSRST17372
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
R. Ranjith, S. Balraj, J. Ganesh, M.C. John Milton, "Effect of Flow Rate on Fiber Morphology and Naringin Release of Electrospun Naringin Loaded Polycaprolactone Nanofibers", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 7, pp.05-08 , September-October-2017.
Journal URL : http://ijsrst.com/IJSRST17372

Article Preview