Biological activity, Spectroscopic and DNA Cleavage of Binuclear Schiff Base Complexes

Authors

  • N. Mahalakshmi  Department of Chemistry, Rajeswari Vedachalam Government Arts College, Chengalpattu, Tamilnadu, India
  • M. R. Kuppusamy  Department of Chemistry, Rajeswari Vedachalam Government Arts College, Chengalpattu, Tamilnadu, India
  • C. Vanitha  Department of Chemistry, Rajeswari Vedachalam Government Arts College, Chengalpattu, Tamilnadu, India

Keywords:

3,3',4,4'-tetraminobiphenyl,Schiff base, binuclear, Antimicrobial, CT-DNA.

Abstract

A new series of transition metal complexes of Cu(II), Ni(II) and VO(II) have been synthesized from the Schiff base (L) derived from 5- iodosalicylaldehyde and 3,3’,4,4’-tetraminobiphenyl. Structural features were obtained from their spectral and analytical data.  The data show that these complexes have composition of [M2(L)]X  type.  (where M = (Cu(II), Ni(II), and VO(II) X=ClO4-, SO42- L = binucleating tetradendate ligand).  The spectral data of the complexes suggest a square–planar geometry around the central metal ion except VO(II) complex which has square–pyramidal geometry. The redox behavior of copper and vanadyl complexes was studied by cyclic voltammetry. The pUC18 DNA cleavage study was monitored by gel electrophoresis method. The results suggest that binuclear Cu(II), Ni(II) and VO(II) complexes cleaves pUC18 DNA in presence of the oxidant H2O2. The invitro antimicrobial activities of the synthesized compounds have been tested against the gram negative and gram positive bacteria’s. The binuclear Schiff base complexes were found to be higher antibacterial activity than the free ligand.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

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Volume 3, Issue 8, November-December-2017

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Research Articles

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[1]
N. Mahalakshmi, M. R. Kuppusamy, C. Vanitha, " Biological activity, Spectroscopic and DNA Cleavage of Binuclear Schiff Base Complexes, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 8, pp.494-500, November-December-2017.