An Overview on Oxidative Stress in Diabetes Mellitus

Authors(5) :-Parvaiz Ahmad Dar, Mohd Ishaq Dar, Mashooq Ahmad Dar, Aarif Ali, Shahnawaz Ahmad Wani

Diabetes mellitus is a complicated metabolic disorder of carbohydrate metabolism that has gravely affected the human health and quality of life. It is a global health crisis, which has been persistently affecting the humanity, irrespective of the socioeconomic profile and geographic location of the population. According to an estimate, every five seconds one person is detected with diabetes somewhere in the world, while someone dies of it every ten seconds. Oxidative stress plays a major role in the onset and progression of diabetes. Many of the common risk factors, such as increased age, unhealthy eating habits and obesity, all contribute to an oxidative environment that may change insulin sensitivity either by increasing insulin resistance or impairing glucose tolerance. The mechanisms by which alteration in insulin sensitivity occurs are often multifactorial and quite complex, involving multiple cell signaling pathways. A common outcome of diabetes is hyperglycemia, which in turn contributes to the progression and disturbance of an overall cellular oxidative status. Oxidative stress seems to be a significant causative agent both in onset as well as progression of diseases.

Authors and Affiliations

Parvaiz Ahmad Dar
Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
Mohd Ishaq Dar
Cancer Pharmacology Division, IIIM, Jammu, Jammu and Kashmir, India
Mashooq Ahmad Dar
Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
Aarif Ali
Department of Biochemistry, University of Kashmir, Jammu and Kashmir, India
Shahnawaz Ahmad Wani
Department of Biochemistry, Jamia Millia Islamia, New Delhi, India

Diabetes Mellitus, Oxidative Stress, Biomarkers

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Publication Details

Published in : Volume 3 | Issue 8 | November-December 2017
Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 731-734
Manuscript Number : IJSRST1738169
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Parvaiz Ahmad Dar, Mohd Ishaq Dar, Mashooq Ahmad Dar, Aarif Ali, Shahnawaz Ahmad Wani, " An Overview on Oxidative Stress in Diabetes Mellitus", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 8, pp.731-734, November-December-2017.
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