Study on the Effects of Ethanolic Extract of Withania somnifera on Hematological Parameters in Male Albino Rats

Authors(5) :-Shahzada Arif Hussain, Nisar Ahmad Bhat, Gulzar Ahmad Bhat, Kusum Singh, Mohmad Ishaq Bhat

The plant Withania somnifera has been used for centuries in traditional medicine in India. However, like many medicinal plants, the belief that things of natural origin are safe may not be entirely true. So present study has planned to find the acute and chronic effects of Ethanolic Extracts of Withania somnifera (EEWS), on haematology indices of Wistar albino rats. The animals were divided into three groups. Two groups served as experimental, which will receive dose at a level of 250 mg/kg and second group act as control which received vehicle only. In experimental groups one receives acute dose and other one receive the chronic dose. The animals were kept in same environmental condition and after 0, 7, 14, 21 and 28 days the haematological parameters were studied. It was noted that during acute administration of EEWS the RBC, WBC, Hb, PCV, ESR, MCH and MCHC have increased at shorter duration but recapitulates to its normal level as compared to the control group. While during chronic administration EEWS these parameters increased significantly to its control group. On the other hand it was noted that on single dose the MCV and Color index have decreased and recouped to the normal value. While during daily administration of the dose these parameters decreased significantly as compared to the control group. In conclusion the present study of EEWS shows control over the hematological parameters without producing any toxicity in albino rats and thus it is safe to use.

Authors and Affiliations

Shahzada Arif Hussain
Department of Zoology Bundelkhand University Jhansi Uttar Pradesh, India
Nisar Ahmad Bhat
Department of Zoology Bundelkhand University Jhansi Uttar Pradesh, India
Gulzar Ahmad Bhat
Department of Zoology Bundelkhand University Jhansi Uttar Pradesh, India
Kusum Singh
Department of Zoology Bundelkhand University Jhansi Uttar Pradesh, India
Mohmad Ishaq Bhat
HNB Central University Garhwal Uttarakhand, India

Withania Somnifera, Haematology, Color Index, Ethanolic Extract.

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Publication Details

Published in : Volume 3 | Issue 8 | November-December 2017
Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 816-824
Manuscript Number : IJSRST1738179
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Shahzada Arif Hussain, Nisar Ahmad Bhat, Gulzar Ahmad Bhat, Kusum Singh, Mohmad Ishaq Bhat, " Study on the Effects of Ethanolic Extract of Withania somnifera on Hematological Parameters in Male Albino Rats", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 8, pp.816-824, November-December-2017.
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