Ultrasound Assisted Convenient and Efficient Protocol for Synthesis of Dihydropyrimidine-2-thiones

Authors

  • Ashok S. Pise  Department of Chemistry, Dada Patil Mahavidyalaya, Karjat, Ahmednagar, Maharashtra, India
  • Arvind S. Burungale  Department of Chemistry, S. M. Joshi College Hadapsar, Pune, Maharashtra, India
  • Ramesh B. Gawade  Department of Chemistry, S. M. Joshi College Hadapsar, Pune, Maharashtra, India
  • Santosh S. Devkate  Department of Chemistry, S. M. Joshi College Hadapsar, Pune, Maharashtra, India
  • Sunil D. Jadhav  Department of Chemistry, Mahatma Phule Mahavidyalaya, Panvel, Raigad, Maharashtra, India

Keywords:

Chalcones, Dihydropyrimidine-2-thione, Cu(I) catalyst, Sodamide, Ultrasound irradiation.

Abstract

Chalones were prepared by condensation of various substituted aromatic aldehydes or heterocyclic aldehydes and acetophenone in alkaline ethanol, while pyrimidine-2-thione derivatives were prepared by condensation of chalcones and thiourea under ultrasonic irradiation at room temperature. The most important advantage of ultrasound irradiation was observed and high yields of products were obtained after 10-15 min. sonication.

References

  1. T. J. Mason ,J. P. Lorimer, Sonochemistry: Theory, Application and Uses of Ultrasound in Chemistry. Wiley, New York (1988).
  2. A. Gaplovsky, M.Gaplovsky, S. Toma S,J. L. Luche,? J. Org Chem,???? (2000),65,8444.
  3. R. R.?? Deshmukh,R.? Rajagopal, K. V. Srinivasan, Chem Commun. (2001), 17,1544.
  4. G. Cravotto, P.? Cintas, ChemSoc ReV,? (2006), 35,180.
  5. W.? Richards, Loomis A J Am Chem Soc, (1927), 49, 3086.
  6. J. L. Luche J. Chem. Society, Chem. Comm. (1992), 798-799.
  7. J. L. Luche Synthetic Communication, (1991), 21, 643-651.
  8. G. W. Anderson, I. F. Halverstadt, W. H. Miller, R. O. Rohin, J. Am. Chem. Soc., (1945), 6, 2197.
  9. C. O. Kappe, Tetrahedron, (1993), 49, 6037.
  10. H. Zang, L. Vrang, K. Bacbro, P. Lind, C. Sahlberg, Antiviral Res, (1995), 28, 331.
  11. J. T. Li, J. F. Han, J.H. Yang, T. S. Li, Ultrason Sonchem, (2003), 10, 119.
  12. J. J. Peng, Y. Q. Deng, Tetrahedron Letters, (2001), 42, 5917.
  13. C. Ramalingan, Y. Kwak, , Tetrahedron, (2208), 64, 5023.
  14. M. Bardhan,C. S. Panda, Indian Journal of Chemistry, (April 2003), 42B, 910-915.
  15. N. D. Moirangthem, W. S. Laitonjam, Indian Journal of Chemistry, (July 2009), 48B, 1023-1026.
  16. T. B. Shah, A. Gupte, M. R. Patel, V. S. Chaudhari, H. Patel, V. C. Patel, Indian Journal of Chemistry,(May 2010), 49B, 578-586.
  17. L. H. V, K. R. Kumar, A. B. Shaik, Aachives of Applied Science Research, (2014), 6(6), 121-127.
  18. Y. Zhang, B. Wang, X. Zhang, J. Huang, C. Liu, Molecules, (2015), 20, 3811-3820. Doi: 10:3390/ molecules20033811.
  19. V. J. Faldu, V. K. Gothalia, V. H. Shah, Indian Journal of Chemistry, (March 2015), 54B, 391-398.
  20. R. Pundeer, Sushma, Indian Journal of Chemistry, (Oct.2015), 54B. 1275-1279.
  21. S. R. N, B. Kalluraya, B. Lingappa, S. Shenoy, Indian Journal of Chemistry, 48B, 1431-1434.
  22. J.S. Ghomi, M. A. Ghasemazadeh, Journal of the Serbian Chemical Society (2011), 76(5), 679-684.

International Journal of Scientific Research in Science and Technology

Downloads

Published

2017-12-31

Issue

Volume 3, Issue 8, November-December-2017

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Ashok S. Pise, Arvind S. Burungale, Ramesh B. Gawade, Santosh S. Devkate, Sunil D. Jadhav, " Ultrasound Assisted Convenient and Efficient Protocol for Synthesis of Dihydropyrimidine-2-thiones, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 8, pp.1073-1075, November-December-2017.