Multicomponent One-Pot Synthesis and Biological Evaluation of Pyrano[2,3-C] Pyrazoles

Authors

  • Nirul V. Gothi  Arts, Science & R. A. Patel commerce college, Bhadran, Gujarat, India

Keywords:

Pyrazoles, Biological Evaluation, One-Pot Synthesis, MCRs, TLC, MeOH

Abstract

Despite recent advances in molecular biology and the progress in combinatorial synthetic methodology, the rate of introduction of new medicines has decreased markedly over the past two decades [1]. Structural diversity in a focused collection of potential therapeutics is believed to increase the positive hit rate. Most medicines in use are still small synthetic organic molecules that often contain a heterocyclic ring.

References

  1. Newton, R. sp2 2002, 16; (see: http://www.sp2.uk.com)
  2. (a) Teague, S. J.; Davis, A. M.; Leeson, P. D.; Oprea, T. I. Angew. Chem., Int. Ed. Engl. 1999, 38, 3743; (b) Armstrong, R. W.; Combs, A. P.; Tempest, P. A.; Brown, S. D.; Keating, T. A. Acc. Chem. Res. 1996, 29, 123.
  3. Domling, A.; Ugi, I. Angew. Chem., Int. Ed. Engl. 2000, 39, 3168.
  4. Bienayme, H.; Hulme, C.; Oddon, G.; Schmitt, P. Chem. Eur. J. 2000, 6, 3321.
  5. Orru, R. V. A.; de Greef, M. Synthesis 2003, 1471.
  6. Tempest, P. A. Curr. Opin. Drug Discovery Dev. 2005, 8, 776.
  7. Lehmann, F.; Holm, M.; Laufer, S. J. Comb. Chem. 2008, 10, 364.
  8. Yuasa, Y.; Tsuruta, H.; Yuasa, Y. Org. Process Res. Dev. 1998, 2, 412.
  9. Mendes, E.; Vernieres, J. C.; Keane, P. E.; Bachy, A. Eur. Patent EP A1 346208, 19891213, 1989.
  10. Litvinov, Y. M.; Shestopalov, A. A.; Rodinovskaya, L. A.; Shestopalov, A. M. J. Comb. Chem. 2009, 11, 914.
  11. Vogel’s Textbook of Practical Organic Chemistry, Fifth Edition, ELBS, Longman Scientific and Technical: England. 1989, Reprinted 1994, 1150.
  12. El-Agrody, A.? M.; Abd El-Latif, M. S.; El-Hady, N. A.; Fakery, A. H.; Bedair, A. H. Molecule 2001, 6, 519.
  13. Bedair, A. H.; El-Hady, N.A.; Abd El-Latif, M. S.; Fakery, A. H.; El-Agrody, A. M.; Il Farmaco 2000, 55, 708.
  14. El-Agrody, A. M.; El-Hakim, M. H.; Abd El-Latif, M. S.; Fakery, A. H.; El-Sayed, E. M.; El-Ghareab, K. A, Acta. Pharm. 2000, 50, 111.
  15. Eid, F. A.; Abd El-Wahab, A. H. F.; El-Hag Ali, G. A. M.; Khafagy, M. M. Acta. Pharm. 2004, 54, 13.
  16. Perez-Perez, M.; Balzarini, J.; Rozenski, J.; De Clercq, E.; Herdewijn, P. Bioorg. Med. Chem. Lett. 1995, 5, 1115.
  17. Shamroukh, A. H.; Zaki, M. E. A.; Morsy. E. M. H.; Abdel-Motti, F. M.; Abdel-Megeid, F. M. E. Arch. Pharm. 2007, 340, 236.
  18. Aytemir, M. D.; Calis, U.; Ozalp, M. Arch. Pharm. 2004, 337, 281.
  19. Melliou, E.; Magiatis, P.; Mitaku, S.; Skaltsounis, A. L.; Pierre, A.; Atassi, G.; Renard, P.; Bioorg. Med. Chem. 2001, 9, 607.
  20. Chabchoub, F.; Messaad, M.; Mansour, H. B.; Chekir-Ghedira, L.; Salem, M. Eur. J. Med. Chem. 2007, 42, 715.
  21. Regaila, H. A.; El-Bayonk, A. K. Hammad, M. Egypt J. Chem. 1979, 20,197.
  22. Shafiee, A.; Bagheri, M.; Shekarchi, M.; Abdollahi, M.; J. Pharm. Sci. 2003, 6, 360.
  23. Ren, X. L.; Li, H. B.; Wu, C.; Yang, H. Z. ARKIVOC 2005, 15, 59.
  24. Almansa, C.; Gomez, L. A.; Cavalcanti, F. L.; de Arriba, A. F.; Garcia-Rafanell, J.; Forn, J. J. Med. Chem. 1997, 40, 547.
  25. Park, H. J.; Lee, K.; Park, S. J.; Ahn. B.; Lee, J. C.; Cho, H.; Lee, K. Bioorg. Med. Chem. Lett. 2005, 15, 3307.
  26. Cali, P.; Naerum, L.; Mukhija, S.; Hjelmencrantz, A. Biorg. Med. Chem. Lett. 2004, 14, 5997.
  27. Prasad. Y. R.; Rao, A. L.; Prasoona, L.; Murali, K.; Kumar, P. R. Bioorg. Med. Chem. Lett. 2005, 15, 5030.
  28. Mojtahedi, M. M.; Jalali, M. R.; Bolourtchian, M. Synth. Commun. 2006, 36, 51.
  29. Pavlik, J. W.; Ervithayasuporn, V.; MacDonald, J. C.; Tantayanon, S. ARKIVOC 2009, 8, 57.
  30. Guard, J. A. M.; Steel, P. J. ARKIVOC 2001, 7, 32.
  31. Kanwal, P.; Gupta, V. K.; Brahmbhatt, D. I.; Patel, M. A. Analytical Sci. 2007, 23, 237.
  32. Jin, T.; Zhao, R.; Li, T. ARKIVOC? 2006, 11, 176.
  33. El-Tamany, E. S.; El-Shahed, F. A.; Mohamed, B. H. J. Serb. Chem. Soc. 1999, 64, 9.
  34. Ismail, Z. H.; Aly, G. M.; El-Degwi, M. S.; Heiba, H. I.; Ghorab, M. M. Egyp. J. Biot. 2003, 13, 73.
  35. Zaki, M. E. A.; Soliman, H. A.; Hiekal, O. A.; Rashad, A. E. Z. Naturforsch C. 2006, 61, 1.
  36. Abdelrazek, F. M.; Metz, P.; Metwally, N. H.; El-Mahrouky, S. F. Arch. Pharm. 2006, 339, 456.
  37. Abdelrazek, F. M.; Metz, P.; Kataeva, O.; Jaeger, A.; El-Mahrouky, S. F. Arch. Pharm. 2007, 340, 543.
  38. Foloppe, N.; Fisher, L. M.; Howes, R.; Potter, A.; Robertson Alan, G. S.; Surgenor, A. E. Bioorg. Med. Chem. 2006, 14, 4792.
  39. Otto, H. H. Arch. Pharm. 1974, 307, 444.
  40. Otto, H. H.; Schmelz, H. Arch. Pharm. 1979, 312, 478.
  41. Klokol, G. V.; Krivokolysko, S. G.; Dyachenko, V. D.; Litvinov, V. P. Chem. Heterocycl. Compd. 1999, 35, 1183.

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Published

2017-12-31

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Section

Research Articles

How to Cite

[1]
Nirul V. Gothi, " Multicomponent One-Pot Synthesis and Biological Evaluation of Pyrano[2,3-C] Pyrazoles , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 8, pp.1288-1295, November-December-2017.