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Mechanistic Effects of microRNA in Pathogenesis of Bovine Mastitis

Authors(9) :-Aarif Ali, Rahil Razak Bhat, Bilal Ahmad Mir, Sheikh Bilal Ahmad, Omer Khalil Baba, S. Mudasir Rashid, Ishraq Hussain, Showkeen Muzamil, Manzoor-ur-Rahman Mir

Mastitis is a multietiological complex disease, characterized by the inflammation of parenchyma of mammary glands there by changing the physical, chemical and bacteriological properties of milk. Bovine mastitis also causes pathological changes in glandular tissues. In the last few years a no of RNA molecules have been discovered and as a result of this the RNA family has been rapidly growing. Of all these RNA molecules that have been found specific attention has been to given to a special class of RNA molecules known as MicroRNAs (mi-RNAs /miRs) .This particular class of RNA molecule has been given more attention because of the fact that they act as powerful regulators of gene expression. Also this class of RNA molecule shows its fundamental impact on the pathogenesis of different pathological events. MicroRNAs (mi-RNAs ) are a group of endogenous non-coding small RNA molecules, usually 20-25 nucleotides in length. MicroRNAs (mi-RNAs ) play an important role in the regulation of gene expression for important biological processes like cellular proliferation and differentiation, tissue development and immune response. MicroRNAs (mi-RNAs ) regulate gene expression post-transcriptionally and are found to be important regulators of epithelial immune responses. Therefore it has became more important to find whether there is any role of mi-RNAs in bovine mastitis or not and also its association to mastitis. Further studies in future needs to be carried out suggest the potential utility of mi-RNAs to serve as biomarkers for the diagnosis of mastitis in dairy cows. The application of mi-RNAs as a potential biomarker has shed light as a tool for detection and verification of a disease in animals.
Aarif Ali, Rahil Razak Bhat, Bilal Ahmad Mir, Sheikh Bilal Ahmad, Omer Khalil Baba, S. Mudasir Rashid, Ishraq Hussain, Showkeen Muzamil, Manzoor-ur-Rahman Mir
Mastitis, MicroRNAs (mi-RNAs ), gene regulation and biomarkers.
  1. Anderson SM, Rudolph MC, McManaman JL and Neville MC 2007. Key stages in mammary gland development. Secretory activation in the mammary gland: It’s not just about milk protein synthesis! Breast Cancer Res. 9:204.
  2. Bartel DP 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
  3. Chen X, Liang H, Zhang J, Zen K, Zhang? CY 2012. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 22, 125-132.
  4. Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, Tian C, Gao S et al 2010. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 20, 1128-1137.
  5. Fatima A, Morris DG 2013. MicroRNAs in domestic livestock. Physiol. Genomics 45, 685-696.
  6. Flicek P, Amode MR, Barrell D, Beal K, Billis K, Brent S, Carvalho-Silva D, Clapham P, et al 2014. Ensembl 2014. Nucleic Acids Res., 42, D749-755.
  7. Goren Y, Kushnir M, Zafrir B, Tabak S, Lewis BS, Amir O 2012. Serum levels of microRNAs in patients with heart failure. Eur. J. Heart Fail. 14, 147-154.
  8. Hou J, Wang P, Lin L, Liu X, Ma F, An H, Wang Z, Cao X 2009. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150-2158.
  9. Howard KM, Jati Kusuma R, Baier SR, Friemel T, Markham L, Vanamala J, Zempleni J, 2015. Loss of mi-RNAs? during processing and storage of cow’s (Bos taurus) milk. J. Agric. Food Chem. 63, 588-592.
  10. Krol J, Loedige I. & Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nature Rev. Genet. 11, 597-610 (2010).
  11. Lawless N, Reinhardt TA, Bryan K, Baker M, Pesch B, Zimmerman D, Zuelke K, Sonstegard T, et al 2014. MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. G3: Genes Genomes Genetics 4, 957-971.
  12. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell. 2003;115:787-98.
  13. Melnik BC, John SM, Schmitz G 2014. Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy. J. Transl. Med. 12, 43.
  14. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, et al 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U.S.A. 105, 10513-10518.
  15. Mitterhuemer SW, Petzl S, Krebs D,? Mehne A, Klanner et al. 2010 Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland. BMC Genomics 11: 138.
  16. O’Connell RM, Rao DS, Chaudhuri A and Baltimore D 2010 Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10: 111-122.
  17. Pasquinelli AE, 2012 MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 13, 271-282.
  18. Prgomet C, Sarikaya H, Bruckmaier RM and Pfaffl MW 2005 Shortterm effects on pro-inflammatory cytokine, lactoferrin and CD14 mRNA expression levels in bovine immunoseparated milk and blood cells treated by LPS. J. Vet. Med. A Physiol. Pathol. Clin. Med. 52: 317-324.
  19. Sun J, Aswath K, Schroeder SG, Lippolis JD, Reinhardt TA, Sonstegard TS 2015. MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics 16, 806.
  20. Wang M, Mois? S, Khan M, Wang J, Loor J, 2012. MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation. J. Dairy Sci. 95, 6529-6535.
  21. Ward JR, Heath PR, Catto JW, Whyte MK, Milo M, et al. 2011 Regulation of neutrophil senescence by microRNAs. PLoS ONE 6: e15810.
  22. Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, Galas DJ, Wang K, 2010. The microRNA spectrum in 12 body fluids. Clin. Chem. 56, 1733-1741.
  23. Winter J, Jung S, Keller S, Gregory RI, Diederichs S 2009. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 11, 228-234.
  24. Xu G, Zhang Y, Jia H, Li J, Liu X 2009 Cloning and identification of microRNAs in bovine alveolar macrophages. Mol. Cell. Biochem. 332: 9-16.
  25. Zhao H, Shen J, Medico L, Wang D, Ambrosone CB, Liu S 2010. A pilot study of circulating mi-RNAs? as potential biomarkers of early stage breast cancer. PLoS ONE 5, e13735.
Publication Details
  Published in : Volume 3 | Issue 8 | November-December 2017
  Date of Publication : 2017-12-31
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 279-282
Manuscript Number : IJSRST173856
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Aarif Ali, Rahil Razak Bhat, Bilal Ahmad Mir, Sheikh Bilal Ahmad, Omer Khalil Baba, S. Mudasir Rashid, Ishraq Hussain, Showkeen Muzamil, Manzoor-ur-Rahman Mir, "Mechanistic Effects of microRNA in Pathogenesis of Bovine Mastitis", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 8, pp.279-282, November-December-2017
URL : http://ijsrst.com/IJSRST173856