Mechanistic Effects of microRNA in Pathogenesis of Bovine Mastitis

Authors

  • Aarif Ali  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Rahil Razak Bhat  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Bilal Ahmad Mir  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Sheikh Bilal Ahmad  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Omer Khalil Baba  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • S. Mudasir Rashid  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Ishraq Hussain  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Showkeen Muzamil  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India
  • Manzoor-ur-Rahman Mir  Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, Sheri Kashmir University of Agricultural Science & Technology-Kashmir (SKUAST-K), Srinagar, J&K, India

Keywords:

Mastitis, MicroRNAs (mi-RNAs ), gene regulation and biomarkers.

Abstract

Mastitis is a multietiological complex disease, characterized by the inflammation of parenchyma of mammary glands there by changing the physical, chemical and bacteriological properties of milk. Bovine mastitis also causes pathological changes in glandular tissues. In the last few years a no of RNA molecules have been discovered and as a result of this the RNA family has been rapidly growing. Of all these RNA molecules that have been found specific attention has been to given to a special class of RNA molecules known as MicroRNAs (mi-RNAs /miRs) .This particular class of RNA molecule has been given more attention because of the fact that they act as powerful regulators of gene expression. Also this class of RNA molecule shows its fundamental impact on the pathogenesis of different pathological events. MicroRNAs (mi-RNAs ) are a group of endogenous non-coding small RNA molecules, usually 20-25 nucleotides in length. MicroRNAs (mi-RNAs ) play an important role in the regulation of gene expression for important biological processes like cellular proliferation and differentiation, tissue development and immune response. MicroRNAs (mi-RNAs ) regulate gene expression post-transcriptionally and are found to be important regulators of epithelial immune responses. Therefore it has became more important to find whether there is any role of mi-RNAs in bovine mastitis or not and also its association to mastitis. Further studies in future needs to be carried out suggest the potential utility of mi-RNAs to serve as biomarkers for the diagnosis of mastitis in dairy cows. The application of mi-RNAs as a potential biomarker has shed light as a tool for detection and verification of a disease in animals.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-31

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Volume 3, Issue 8, November-December-2017

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Research Articles

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How to Cite

[1]
Aarif Ali, Rahil Razak Bhat, Bilal Ahmad Mir, Sheikh Bilal Ahmad, Omer Khalil Baba, S. Mudasir Rashid, Ishraq Hussain, Showkeen Muzamil, Manzoor-ur-Rahman Mir, " Mechanistic Effects of microRNA in Pathogenesis of Bovine Mastitis, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 8, pp.279-282, November-December-2017.