Synthesis, Characterization and Evaluation of Antifungal and Antibacterial Activities of Some Quinazoline Derivatives

Authors(2) :-A. A. Kale, K. M. Durgade

Present work includes synthesis of 2-{[2-(piperazin-1-yl)quinazolin-4-yl]amino}ethan-1-ol (IV) , N2, N4-di p-tolylquinazoline-2,4- diamine (V) and N2, N4-bis(4-chlorophenyl)quinazoline-2,4-diamine (VI) which are quinazoline derivatives and out of these three quinazoline derivatives N2, N4-bis(4-chlorophenyl)quinazoline-2,4-diamine (VI) have shown “antifungal activity” against fungus “Aspergillus flavus” and “antibacterial activity” against bacteria “Pseudomonas”. At first 2- amino benzoic acid react with urea at temperature 130 ºC to 140ºC to gives Quinazolin-2,4-diol (I) which on further reaction with phosphorus oxychloride at 150 ºC for 24 hr. to gives second product 2,4-dichloroquinazoline (II). Then 2-4-dichloroquinazoline (II) reacts with 2-aminoethan-1-ol and piperazine to gives 2-{[2-(piperazin-1-yl)quinazolin-4-yl]amino}ethan-1-ol (IV) and when p-toluidine react with 2-4-dichloroquinazoline (II) to gives N2, N4-di p-tolylquinazoline-2,4- diamine (V) and again this 2,4-dichloroquinazoline (II) react with p-chloroanline to gives N2, N4-bis(4-chlorophenyl) quinazoline-2,4-diamine (VI) which characterized by I. R., 1HNMR and 13CNMR.

Authors and Affiliations

A. A. Kale
Post Graduate Department of Chemistry, Annasaheb Awate College, Manchar, Ambegoan, Pune, Maharashtra, India
K. M. Durgade
Department of Chemistry, Prof. Ramkrishna More College, Aakurdi, Pune, Maharashtra, India

Quinazoline Derivative, Antifungal Activity, Antibacterial Activity, N2, N4-Di P-Tolylquinazoline-2, 4-Diamine, N2, N4-Bis (4-Chlorophenyl) Quinazoline-2, 4-Diamine, Quinazolin-2, 4-Diol, 2,4-- Dichloroquinazoline

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Publication Details

Published in : Volume 3 | Issue 9 | November-December 2017
Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 17-23
Manuscript Number : IJSRST173905
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

A. A. Kale, K. M. Durgade, " Synthesis, Characterization and Evaluation of Antifungal and Antibacterial Activities of Some Quinazoline Derivatives", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.17-23, November-December-2017.
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