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A simple, convenient Grape Juice Catalyzed Synthesis of Dihydropyrimidinone/thione by Grindstone Technique : A Green chemistry Approach

Authors(5) :-G. M. Nazeruddin, S. S. Mulani, Y. I. Shaikh, Samir S. Shaikh, Khursheed Ahmed

Multicomponent reactions (MCRs) are chemical reactions in which three or more compounds react to form a single product. In the present work Biginelli reaction was accomplished just by grinding equimolar quantities of ethyl acetoacetate, Urea/thiourea and aryl aldehyde with grape juice as a catalyst for 15 to 20 minutes at ambient condition. The crude product was recrystallized by ethanol. This protocol is a greener approach for organic transformations, thus facilitating efficient synthesis of bioactive compounds in environmentally benign way with shorter reaction time, mild reaction conditions, and easy workup with excellent yield of the product.
G. M. Nazeruddin, S. S. Mulani, Y. I. Shaikh, Samir S. Shaikh, Khursheed Ahmed
Green Chemistry, Grape Juice, Multicomponent Reaction, Grindstone Technique.
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Publication Details
  Published in : Volume 3 | Issue 9 | November-December 2017
  Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 46-50
Manuscript Number : IJSRST173910
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
G. M. Nazeruddin, S. S. Mulani, Y. I. Shaikh, Samir S. Shaikh, Khursheed Ahmed, "A simple, convenient Grape Juice Catalyzed Synthesis of Dihydropyrimidinone/thione by Grindstone Technique : A Green chemistry Approach", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.46-50, November-December-2017
URL : http://ijsrst.com/IJSRST173910