A simple, convenient Grape Juice Catalyzed Synthesis of Dihydropyrimidinone/thione by Grindstone Technique : A Green chemistry Approach

Authors

  • G. M. Nazeruddin  Department of Chemistry and Post Graduate Research Centre, Abeda Inamdar Senior College, Pune, Maharashtra, India
  • S. S. Mulani  Department of Chemistry and Post Graduate Research Centre Poona College of Arts, Science and Commerce, Pune, Maharashtra, India
  • Y. I. Shaikh  Department of Chemistry and Post Graduate Research Centre, Abeda Inamdar Senior College, Pune, Maharashtra, India
  • Samir S. Shaikh  Department of Chemistry Post Graduate Centre, G.M. Arts, Commerce and Science College, Narayngaoan, Pune, Maharashtra, India
  • Khursheed Ahmed  Department of Chemistry and Post Graduate Research Centre, Abeda Inamdar Senior College, Pune, Maharashtra, India

Keywords:

Green Chemistry, Grape Juice, Multicomponent Reaction, Grindstone Technique.

Abstract

Multicomponent reactions (MCRs) are chemical reactions in which three or more compounds react to form a single product. In the present work Biginelli reaction was accomplished just by grinding equimolar quantities of ethyl acetoacetate, Urea/thiourea and aryl aldehyde with grape juice as a catalyst for 15 to 20 minutes at ambient condition. The crude product was recrystallized by ethanol. This protocol is a greener approach for organic transformations, thus facilitating efficient synthesis of bioactive compounds in environmentally benign way with shorter reaction time, mild reaction conditions, and easy workup with excellent yield of the product.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-15

Issue

Volume 3, Issue 9, November-December-2017

Section

Research Articles

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How to Cite

[1]
G. M. Nazeruddin, S. S. Mulani, Y. I. Shaikh, Samir S. Shaikh, Khursheed Ahmed, " A simple, convenient Grape Juice Catalyzed Synthesis of Dihydropyrimidinone/thione by Grindstone Technique : A Green chemistry Approach, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 9, pp.46-50, November-December-2017.