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Synthesis and Characterization of SomeBiologically Potent 2-(2-butyl-4-chloro-1H-imidazol-5-yl)-4H-chromen-4-onederivatives

Authors(5) :-S. S. Gaikwad, D. V. Sonawane, D. N. Gaikwad, M. D. Sangale, Y. V. Bare

In the present investigation, a series of novel chromone derivatives containing imidazole moiety has been synthesized. The condensation of 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde with various substituted o-hydroxy acetophenones in the presence of 40% KOH in PEG- 400 gives the chalcones. Oxidative cyclisation of chalcones withcatalytic amount of iodine in the presence of DMSO gives chromones. Chalcones and Chromones were obtained in satisfactory yield.The structure of intermediate and titled compounds was confirmed by spectral tools.
S. S. Gaikwad, D. V. Sonawane, D. N. Gaikwad, M. D. Sangale, Y. V. Bare
Chalcones, Chromones, O-Hydroxyacetophenones, Imidazole, PEG-400
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Publication Details
  Published in : Volume 3 | Issue 9 | November-December 2017
  Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 69-74
Manuscript Number : IJSRST173914
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
S. S. Gaikwad, D. V. Sonawane, D. N. Gaikwad, M. D. Sangale, Y. V. Bare, "Synthesis and Characterization of SomeBiologically Potent 2-(2-butyl-4-chloro-1H-imidazol-5-yl)-4H-chromen-4-onederivatives", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.69-74, November-December-2017
URL : http://ijsrst.com/IJSRST173914