Synthesis and Characterization of SomeBiologically Potent 2-(2-butyl-4-chloro-1H-imidazol-5-yl)-4H-chromen-4-onederivatives

Authors

  • S. S. Gaikwad  P.G. Department of Chemistry, Annasaheb Awate Arts, Commerce, Hutatma Babu Genu Science College, Manchar, Tal.-Ambegaon, Pune , Maharashtra, India
  • D. V. Sonawane  P.G. Department of Chemistry,R.B.N.B. College, Shrirampur, Ahmednagar (MS), India
  • D. N. Gaikwad  P.G. Department of Chemistry, Annasaheb Awate Arts, Commerce, Hutatma Babu Genu Science College, Manchar, Tal.-Ambegaon, Pune , Maharashtra, India
  • M. D. Sangale  P.G. Department of Chemistry, Annasaheb Awate Arts, Commerce, Hutatma Babu Genu Science College, Manchar, Tal.-Ambegaon, Pune , Maharashtra, India
  • Y. V. Bare  JubilantChemsys Ltd., Noida, Uttar Pradesh, India

Keywords:

Chalcones, Chromones, O-Hydroxyacetophenones, Imidazole, PEG-400

Abstract

In the present investigation, a series of novel chromone derivatives containing imidazole moiety has been synthesized. The condensation of 2-butyl-4-chloro-1H-imidazole-5-carbaldehyde with various substituted o-hydroxy acetophenones in the presence of 40% KOH in PEG- 400 gives the chalcones. Oxidative cyclisation of chalcones withcatalytic amount of iodine in the presence of DMSO gives chromones. Chalcones and Chromones were obtained in satisfactory yield.The structure of intermediate and titled compounds was confirmed by spectral tools.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-15

Issue

Volume 3, Issue 9, November-December-2017

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Research Articles

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How to Cite

[1]
S. S. Gaikwad, D. V. Sonawane, D. N. Gaikwad, M. D. Sangale, Y. V. Bare, " Synthesis and Characterization of SomeBiologically Potent 2-(2-butyl-4-chloro-1H-imidazol-5-yl)-4H-chromen-4-onederivatives, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 9, pp.69-74, November-December-2017.