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Synthesis, Spectral Characterization, Molecular Docking, Antimicrobial And Antioxidant Evaluation Of Pharmacophores 1, 3-Diones with Their Transition Metal Complexes

Authors(1) :-Dayanand M. Suryawanshi

Three series of 1, 3-diones 4(LA- LC) and their transition metal (II) complexes 5LA (a-e), 5LB (a-e) and 5LC (a-e) have been synthesized, spectroscopically characterized and their in vitro efficacies were evaluated. Bidentate ligands were derived from substituted aromatic acids and substituted ortho hydroxy acetophenone under ultrasound irradiation methods at low temperature. The simple substitution reactions between the metal nitrate and ligands yielded the titled complexes. However, in situ procedure gives high yield with formation of single products as evident by TLC. Elemental analysis, IR, 1H and 13C-NMR , Masss pectra, UV-Vis., magnetic susceptibility and conductance measurements were done to characterize the ligands and their metal complexes [where, M= Mn (II), Fe (III), Co (II), Ni (II) and Cu (II) ]. All the evidences suggested that the complexes have octahedral geometry. The stoichiometry of the complexes was found to be 1:2 (metal: ligand). The conductivity data show that the complexes are non-electrolyte in nature. The antioxidants activity of the ligands and their metal (II) complexes have been carried out using DPPH free radical scavenging activity and found to be most effective. The antibacterial and antifungal activity of the ligands and their complexes have been carried out and on the basis the molecular docking studyagainst the peptide deformylase of the most effective complexes has been reported.
Dayanand M. Suryawanshi
1, 3-diones, Metal complexes, Antimicrobial, Antioxidants and Molecular docking.
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Publication Details
  Published in : Volume 3 | Issue 9 | November-December 2017
  Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 109-115
Manuscript Number : IJSRST173922
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Dayanand M. Suryawanshi, "Synthesis, Spectral Characterization, Molecular Docking, Antimicrobial And Antioxidant Evaluation Of Pharmacophores 1, 3-Diones with Their Transition Metal Complexes", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.109-115, November-December-2017
URL : http://ijsrst.com/IJSRST173922