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Synthesis, Anti-Tubercular and Antimicrobial Screening of 2-aryl/benzyl-2'-Benzyl-4'-Methyl-4,5'-Bithiazole Derivatives

Authors(2) :-Yogita K. Abhale, Pravin C. Mhaske

A small focused library of 2-aryl/benzyl-2'-benzyl-4'-methyl-4,5'-bithiazole derivatives, 7a-ag has been efficiently synthesized. The chemical structure of the newly synthesized compounds was determined by analytical and spectral methods. The title compounds were screened for inhibitory activity against Mycobacterium smegmatis MC2 155 strain while the antimicrobial properties were investigated against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Saccharomyces cerevisiae and Candida albicans. Most of the synthesized compounds showed moderate antitubercular activity while some compounds showed good antibacterial activity against B. subtilis. This study provides valuable directions to our ongoing endeavour of rationally designing more potent antimycobacterial agent.
Yogita K. Abhale, Pravin C. Mhaske
Bisthiazoles, Mycobacterium Smegmatis, Antibacterial Activity.
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Publication Details
  Published in : Volume 3 | Issue 9 | November-December 2017
  Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 127-137
Manuscript Number : IJSRST173925
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Yogita K. Abhale, Pravin C. Mhaske, "Synthesis, Anti-Tubercular and Antimicrobial Screening of 2-aryl/benzyl-2'-Benzyl-4'-Methyl-4,5'-Bithiazole Derivatives", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.127-137, November-December-2017
URL : http://ijsrst.com/IJSRST173925