Synthesis, Anti-Tubercular and Antimicrobial Screening of 2-aryl/benzyl-2'-Benzyl-4'-Methyl-4,5'-Bithiazole Derivatives

Authors

  • Yogita K. Abhale  Post-Graduate, Department of Chemistry, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, Sangamner, Ahmednagar, India
  • Pravin C. Mhaske  Post Graduate Department of Chemistry, S. P. Mandali’s, Sir Parashurambhau College, Tilak Road, Pune, India

Keywords:

Bisthiazoles, Mycobacterium Smegmatis, Antibacterial Activity.

Abstract

A small focused library of 2-aryl/benzyl-2'-benzyl-4'-methyl-4,5'-bithiazole derivatives, 7a-ag has been efficiently synthesized. The chemical structure of the newly synthesized compounds was determined by analytical and spectral methods. The title compounds were screened for inhibitory activity against Mycobacterium smegmatis MC2 155 strain while the antimicrobial properties were investigated against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Saccharomyces cerevisiae and Candida albicans. Most of the synthesized compounds showed moderate antitubercular activity while some compounds showed good antibacterial activity against B. subtilis. This study provides valuable directions to our ongoing endeavour of rationally designing more potent antimycobacterial agent.

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International Journal of Scientific Research in Science and Technology

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Published

2017-12-15

Issue

Volume 3, Issue 9, November-December-2017

Section

Research Articles

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How to Cite

[1]
Yogita K. Abhale, Pravin C. Mhaske, " Synthesis, Anti-Tubercular and Antimicrobial Screening of 2-aryl/benzyl-2'-Benzyl-4'-Methyl-4,5'-Bithiazole Derivatives, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 9, pp.127-137, November-December-2017.