Polyethylene Glycol (PEG-400): As Green Reaction Media for Rapid Synthesis of Preparation of Isoxazolinederivatives and Its Antimicrobial Screening

Authors(5) :-Santosh S. Chobe, Thansingh B.Pawar, Bapusaheb. S. Jagdale, Bhaskar S. Dawane, Dinesh T. Gajulwar

We wish to describe an efficient and rapid synthesis of isoxazolines by the reaction of substituted pyrazol-5-one were condensed with hydroxylamine hydrochloride in presence of clay (pH =12.5) and PEG-400 as a green reaction media. Herein, we report the conventional condensation method of substituted pyrazol-5-one with hydroxylamine hydrochloride in PEG-400 as reaction solvent at mild reaction condition. Structures of the synthesized compounds were confirmed by the spectral analysis. Furthermore, all the synthesized compounds were evaluated for their antimicrobial screening against several pathogenic representatives, these newly synthesized compounds were screened for their antimicrobial activity against bacterial strain Escherichia coli (MTCC-443), Bacillus subtilis (MTCC-441), Staphylococcus aureus (MTCC-96) and Salmonella typhi. (MTCC-98). The antifungal activity was evaluated against Aspergillus niger (MTCC-1781), Aspergillus flavus (MTCC-3008), Candida albicans (MTCC-227) and Penicillium chrysogenum (MTCC-160).The result revealed that most of the compounds showed good to moderate Antimicrobial screening. The major advantages of this protocol are it gives excellent yields of products, work up procedure and isolation is easier, Procedure is green and environmentally benign, shorter reaction times.

Authors and Affiliations

Santosh S. Chobe
Organic research Laboratory, P.G.Department of Chemistry. Loknete Vyankatrao Hiray Arts,Science and commerce Mahavidyalaya,Nashik (MS) India
Thansingh B.Pawar
Organic research Laboratory, P.G.Department of Chemistry. Loknete Vyankatrao Hiray Arts,Science and commerce Mahavidyalaya,Nashik (MS) India
Bapusaheb. S. Jagdale
Organic research Laboratory, P.G.Department of Chemistry. Loknete Vyankatrao Hiray Arts,Science and commerce Mahavidyalaya,Nashik (MS) India
Bhaskar S. Dawane
Organic Research Laboratory, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, (MS) India
Dinesh T. Gajulwar
P.G. Dept. of Chemistry, Gramonnati Mandal’s Arts, Commerce & Science College, Narayngaon Pune, India

Pyrazolone, Isoxazoline, PEG-400, Clay(pH =12.5) andAntimicrobial activity.

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Publication Details

Published in : Volume 3 | Issue 9 | November-December 2017
Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 187-191
Manuscript Number : IJSRST173938
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Santosh S. Chobe, Thansingh B.Pawar, Bapusaheb. S. Jagdale, Bhaskar S. Dawane, Dinesh T. Gajulwar, " Polyethylene Glycol (PEG-400): As Green Reaction Media for Rapid Synthesis of Preparation of Isoxazolinederivatives and Its Antimicrobial Screening", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.187-191, November-December-2017.
Journal URL : http://ijsrst.com/IJSRST173938

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