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Synthesis and antimycobacterial evaluation of new 1-substituted benzyl-4-(1-phenyl-3-substituted phenyl-1H-pyrazol-4-yl)-1H-1,2,3-triazole Derivatives

Authors(4) :-Pravin Mhaske, Shivaji Jagdale, Abhijit Shinde, Vivek Bobade

A new series of 1-substituted benzyl-4-(1-phenyl-3-substituted phenyl-1H-pyrazol-4-yl)-1H-1,2,3-triazole derivatives, 5a-k have been synthesized. The structure of the newly synthesized compounds was determined by spectral analysis. The title compounds were screened for their preliminary antitubercular activity against Mycobacterium tuberculosis H37Ra active and dormant (MTB, ATCC 25177) and antimicrobial activity against standard Gram-negative bacteria, Escherichia coli (NCIM 2576), Pseudomonas flurescence (NCIM 2059) and Gram-positive bacteria, Staphylococcus aureus (NCIM 2602), Bacillus subtilis (NCIM 2162). Most of the synthesized compounds reported moderate activity against M. tuberculosis H37Ra and Bacillus subtilis strains.
Pravin Mhaske, Shivaji Jagdale, Abhijit Shinde, Vivek Bobade
1,2,3-Triazole, Pyrazole, Antitubercular Activity, Antibacterial Activity
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Publication Details
  Published in : Volume 3 | Issue 9 | November-December 2017
  Date of Publication : 2017-12-15
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 215-221
Manuscript Number : IJSRST173943
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Pravin Mhaske, Shivaji Jagdale, Abhijit Shinde, Vivek Bobade, "Synthesis and antimycobacterial evaluation of new 1-substituted benzyl-4-(1-phenyl-3-substituted phenyl-1H-pyrazol-4-yl)-1H-1,2,3-triazole Derivatives ", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 9, pp.215-221, November-December-2017.
Journal URL : http://ijsrst.com/IJSRST173943

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