Synthesis and Antibacterial Activity of Novel 3-Hydroxy Benzoic Acid Hybrid Derivative [Part I]

Authors(3) :-Maruti S. Satpute, Vijay D. Gangan, Indu Shastri

3-hydroxy benzoic acid is an organic chemical which can be obtained naturally as well as synthetically. The literature survey reveals its various biological properties viz. antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, anti-platelet aggregating, nematicidal, antiviral, antioxidant etc. It is also reported to be used as preservative in many drugs, cosmetic products, pharmaceuticals, food and beverages. Some derivatives of 3-hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acid induced oedema and used in management of sickle cell disease. It is also has wide applications in perfumery industries. In this paper, novel ester / hybrid derivative of 3- Hydroxy benzoic acid was synthesized and tested for its potential antibacterial activity. This combinatorial synthesis of novel 3-Hydroxy benzoic ester / hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates.

Authors and Affiliations

Maruti S. Satpute
Department of Chemistry, R. D. National College and W. A. Science College, Linking Road, Bandra (W), Mumbai, Maharashtra, India
Vijay D. Gangan
Department of Chemistry, Loba R & D Centre, Loba Chemie Pvt. Ltd., Plot No. D - 22, Tarapur MIDC, Boisar, Palghar, Maharashtra, India
Indu Shastri
Department of Chemistry, R. D. National College and W. A. Science College, Linking Road, Bandra (W), Mumbai, Maharashtra, India

3-Hydroxy Benzoic Acid, IR, 1HNMR, TOF MS, DCC, DMAP, Biological Activities Antibacterial, Ditch-Plate Method.

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Publication Details

Published in : Volume 4 | Issue 11 | November-December 2018
Date of Publication : 2018-12-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 369-374
Manuscript Number : IJSRST18401159
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Maruti S. Satpute, Vijay D. Gangan, Indu Shastri, " Synthesis and Antibacterial Activity of Novel 3-Hydroxy Benzoic Acid Hybrid Derivative [Part I], International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 11, pp.369-374, November-December-2018. Available at doi : https://doi.org/10.32628/IJSRST18401159
Journal URL : http://ijsrst.com/IJSRST18401159

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