Chemotherapeutic effect of Farnesol against N-Diethyl Nitrosamine (DEN) Induced Experimental Hepatocellular Carcinoma in Rats

Authors

  • Gopalakrishnan Balaraman  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Ashok M  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Satheesh Kanna V  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • PalanisamyK  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India
  • Dr. Devaki T  Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamilnadu, India

Keywords:

Hepatocellular Carcinoma, Diethyl Nitrosamine, Farnesol, Anticancer Property.

Abstract

Hepatocellular carcinoma (HCC), commonly known as liver cancer, is a most prevalent cancer which accounts for increased morbidity and mortality in developed countries. Currently available drugs for the treatment of liver cancer cause detrimental side effects. Hence search for plant - based drugs with fewer side effects continues. Farnesol which is found in the essential oils of ambrette seeds, citronella, and chamomile possess a wide range of pharmacological properties.  In the present study an attempt has been made to evaluate the anticancer effect of farnesol against DEN- induced hepatocellular carcinoma in rats. Oral treatment of  farnesol  (25 mg/kg bw) to tumor bearing rats daily for four weeks was found to be effective against DEN- induced hepatocellular carcinoma in rats. The levels of tumor markers such as alpha fetal protein and carcinoembryonic antigen were decreased upon farnesol treatment.  The increased levels of DNA and RNA were found to be decreased upon treatment with farnesol. There was a significant improvement in protein content. The increased activities of AST, ALT, ALP, ACP, 5’-ND, gamma-GT and LDH in serum of experimental rats were significantly decreased to near normal levels. Oral administration of farnesol to DEN- induced rats significantly decreased the levels of Phase I enzymes and increased the levels of Phase II enzymes in liver tissues to near normalcy. Elevated levels of glycocomponents of glycoproteins such as hexose, hexosamine and sialic acid in plasma and liver tissues were significantly decreased upon farnesol treatment.  The results of the present study indicate that farnesol exerts chemotherapeutic potential in DEN- induced hepatocellular carcinoma in rats.

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International Journal of Scientific Research in Science and Technology

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Published

2018-10-30

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Volume 4, Issue 10, September-October-2018

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Research Articles

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[1]
Gopalakrishnan Balaraman, Ashok M, Satheesh Kanna V, PalanisamyK, Dr. Devaki T, " Chemotherapeutic effect of Farnesol against N-Diethyl Nitrosamine (DEN) Induced Experimental Hepatocellular Carcinoma in Rats, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 10, pp.326-337, September-October-2018.