Manuscript Number : IJSRST1841092
Identification of Cytotoxicity of Marine Sponge Dendrilla Membranosa Against L929 Cell Line
Authors(4) :-Joicy Abraham, Mahija S. P, Jency George, Dr. Manjusha W. A Marine sponges are rich sources of pharmacological active compound. Marine sponge, Dendrilla membranosa was collected from the Vizhingam coast. The sponge extract was tested against eight human bacterial pathogens. The bioactive compounds present in marine sponge were determined by GC-MS analysis. The cytotoxic effect of the sponge was evaluated by using MTT assay. The extracts showed potent anti-bacterial activity against Staphylococcus aureus, Bacillussubtilis, Streptococcus pyogens. The bioactive compound present in marine sponge was identified by GC-MS analysis and the compounds are ethane, butane, formate pentane, Alpha d-galactopyranoside, 2-Ethylhexyl2-ethylhexanoate, Hexahydro hexitol, Styrene, Alpha-d glucopyranoside 1-pentyl-2-proppyl-1-octene, nonadecane, 1,2-benzenedicarboxylic acid, bis-2, Octanoic acid. The test material showed none cytotoxic response to fibroblasts cells. The results of present investigation revealed that, Dendrilla membranosa is a potential source of novel anticancer and antibacterial leads.
Joicy Abraham Dendrilla Membranosa, GC-MS, Anticancer Activity, Antimicrobial Activity, Antifungal Activity Publication Details
Published in : Volume 6 | Issue 1 | January-February 2019 Article Preview
Research Scholar, Interdisciplinary Research Centre, Department of Biotechnology, MS University, Tirunelveli, India
Mahija S. P
Research Scholar, Interdisciplinary Research Centre, Department of Biotechnology, MS University, Tirunelveli, India
Jency George
Research Scholar, Interdisciplinary Research Centre, Department of Biotechnology, MS University, Tirunelveli, India
Dr. Manjusha W. A
Head and Assistant Professor of Biotechnology Department, Malankara Catholic College, MS University, Tirunelveli, India
Date of Publication : 2019-01-30
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 147-152
Manuscript Number : IJSRST1841092
Publisher : Technoscience Academy
Journal URL : https://ijsrst.com/IJSRST1841092
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