Synthesis, Characterization and Evaluation of Biological Properties of Transition Metal Chelates with Schiff base Ligands Derived from Glutaraldehyde with L-Leucine

Authors(3) :-S. Ajith Sinthuja, Y. Christabel Shaji , G. Leema Rose

A nitrogen-oxygen Schiff base HL derived from Glutaraldehyde and L-Leucine has been reacted with different divalent metal ions in 2:1 molar ratio, producing neutral complexes . All compounds were characterized using physico-chemical and spectroscopic methods namely elemental analysis, melting point, magnetic moment measurement, conductivity measurement, UV-Vis, IR, 1HNMR spectroscopy and XRD measurements. They were further analysed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. The IR data demonstrated the tetradentate binding of Schiff base ligand. The molar conductivity values were relatively low , showing their nonelectrolytic nature. Room temperature magnetic susceptibility measurements revealed that the nature of Ni(II) and Cu(II) complexes were paramagnetic. The in vitro antimicrobial activities of all the compounds were screened against different microbial species by Disc Diffusion method and showed better activity compared to parent drug and control drug.

Authors and Affiliations

S. Ajith Sinthuja
Department of Chemistry, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India
Y. Christabel Shaji
Department of Chemistry, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India
G. Leema Rose
Department of Chemistry, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India

Schiff base, Metal complexes, IR, XRD, Antimicrobial activity

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Publication Details

Published in : Volume 4 | Issue 2 | January-February 2018
Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 587-582
Manuscript Number : IJSRST1841138
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

S. Ajith Sinthuja, Y. Christabel Shaji , G. Leema Rose, " Synthesis, Characterization and Evaluation of Biological Properties of Transition Metal Chelates with Schiff base Ligands Derived from Glutaraldehyde with L-Leucine", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 2, pp.587-582, January-February-2018.
Journal URL : https://ijsrst.com/IJSRST1841138
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