Developmental Neurotoxicity of Cadmium on Cholinergic and Bioenergetics Systems - Protectve Role of Vitamin-C

Authors

  • Jyostna V  Department of Biotechnology Acharya Nagarjuna University Nagarjunanagar, Guntur-522510, Andhra Pradesh, India
  • Sudhakar Podha  Department of Biotechnology Acharya Nagarjuna University Nagarjunanagar, Guntur-522510, Andhra Pradesh, India

Keywords:

Cadmium, Vitamin - C, Neurotransmitters, Neurotoxicity, ATPases

Abstract

Cadmium (Cd) is a potent neurotoxic metal and an environmental toxin, which induces membrane disturbances in nervous system and leads to neurological impairment. Enzymatic activities of Acetylcholine (ACh), Acetylcholine esterase (AChE), Na+/K+-ATPase and Mg2+-ATPase in synaptosomal fractions of cerebral cortex, cerebellum and hippocampus of rat brain were studied. Subcutaneous administration of Cd (2mg/kgbw and 5mg/kgbw) to rats daily for a period of 30 days were found to decrease the activity of AChE,Na+/K+-ATPase,Mg2+-ATPase and increase was seen in ACh activity. The aim of the study was to examine the ability of Vitamin –C to prevent and recover the cadmium induced neurotoxicity. Our results indicate that Cd induced alterations in these enzymes in dose dependent manner, and vitamin-C can restore the alteration of these enzymes to control levels either partially or totally in Cd exposed rats, which suggest that Vitamin–C act as a neuroprotective agent and protects the brain from toxic effects of Cd.

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International Journal of Scientific Research in Science and Technology

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Published

2018-02-28

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Volume 4, Issue 2, January-February-2018

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Research Articles

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[1]
Jyostna V, Sudhakar Podha, " Developmental Neurotoxicity of Cadmium on Cholinergic and Bioenergetics Systems - Protectve Role of Vitamin-C, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 2, pp.1004-1013, January-February-2018.