Home > Archives > IJSRST1841247 IJSRST-Library

Role of Nitrogen-Containing Natural Heterocyclic Compounds in Medical Science : A Mini Review

Authors(3) :-Narendra Nirwan, Chandresh Pareek, Anil Chohadia

Heterocyclic compounds constitute the largest and most varied family of organic compounds. Nitrogen-containing heterocyclic compounds are an important class of heterocyclic compounds that have paid the significant contribution towards medicinal chemistry, biochemistry, material science and also another area of science. N-heterocycles show a large number of biological activities such as antifungal, anti-inflammatory, antibacterial, antioxidant, anticonvulsant, antiallergic, enzyme inhibitors, herbicidal, anti-HIV, antidiabetic, anticancer, insecticidal etc. This paper reviews the most biological active N-heterocyclic compounds which were synthesized or extracted from the plants.
Narendra Nirwan, Chandresh Pareek, Anil Chohadia
Heterocyclic compounds, medicinal chemistry, biological activity, indole, imidazole.
  1. Balaban, A. T.; Oniciu DC, Katritzky, A.R. Aromaticity as a Cornerstone of Heterocyclic Chemistry. Chem. Rev. 2004, 104, 2777-2812.
  2. Bacolini, G. Topics Heterocycl. Syst. Synth. React. Prop. 1996, 1, 103.
  3. Brichacek, M.,; Njardarson, J.T. Creative approaches towards the synthesis of 2,5-dihydro-furans, thiophenes, and pyrroles. One method does not fit all. Org. Biomol. Chem. 2009, 7, 1761-1770.
  4. Sheldon, R. A. Catalysis: the key to waste minimization. J. Chem. Technol. Biotechnol.1997, 68, 381-388.
  5. Dabholkar, V.V.; Ansari, F.Y. Novel pyrimidine derivatives by sonication and traditional thermal methods. Green Chem. Lett. Rev.2010, 3, 245-248.
  6. Gupta, M. Int. J. Physical, Chem. Mat. Sci., 2015, 4(1), 21-24.
  7. Moan, J.; Berg, K. Photochem. Photobio. 2008, 53, 549.
  8. Dolphin, D.; and Felton, R. H. Acc. Chem. Res. 1974, 7, 26.
  9. Dolphin, D. The Porphyrins, Academic, New York, 1978, Vols. I-VII.
  10. Hardison, R. American Scientist, 1999, 87(2), 126-137.
  11. Thomas, M.; Markus, U.; Karl-Hans, O.; Bernhard, K. Angew. Chem. Intl. Ed. 2007, 46, 8699-8702.
  12. Purves; Dale; George, J. A.; David, F.; William, C. H. Antony Samuel LaMantia, James O. McNamara and Leonard E. W.Neuroscience 2008, 4th Ed. 137-138.
  13. Walsh, H.; Govind, A. P.; Mastro R. J. Biol. Chem. 2008, 283(10), 6022-6032.
  14. Tajender, V.;Jasjeet, S.;Indian J. Chest Dis. Allied Sci. 2006, 48, 205-206.
  15. Fattore, L.; Piras, G.; Corda, M. G.; Giorgi, O. Neuropsychopharmacology, 2009, 34(5), 1091-1101.
  16. Stefano, G. B.; Zhu, W.; Cadt, P.; Bilfinger, T. V.; Mantione, K. J. Physiol. Pharmacol. 2004, 55(1), 279-288.
  17. Maitra, N.; Verma, R.N.; Desai, V. A. J. Obstet. Gynecol. India, 2007, 57(2), 131-134.
  18. Sandu, J. S.; Dhiman, A.; Mahajan, R.; Sandhu, P. Indian J Nephrol, 2003, 13, 64-68.
  19. Kesse-Guyot, E.; Bertrais, S.; Peneau, S.; Estaquio, C.; Dauchet, L.; Vergnaud, A. C.; Czernichow, S. and Bellisle, F. Eur. J. Clin. Nut. 2009, 63, 521.
  20. Barbachyn, M. R.; Ford, C.W. Angew. Chem., Int. Ed. 2003, 42, 2010-2023.
  21. Brickner, S. J. Cur. Pharm. Des. 1996, 2, 175-194.
  22. Gravestock, M. B. Curr. Opin. Drug. Discov. Devel. 2005, 8, 469-477.
  23. Bush, K.; Macielag, M.; Weidner-Wells, M. Curr. Opin. Microbiol. 2004, 7, 466-476.
  24. Renslo, A. R.; Luehr, G. W.; Gordeev, M. F. Bioorg. Med. Chem. Lett. 2006, 14, 4227-4240.
  25. Hutchinson, D. K. Curr. Top. Med. Chem. 2003, 3, 1021-1042.
  26. Hollingsworth, R. I.; Wang, G.; Padmakumar, R.; Mao, J.; Zhang, H.; Dai, Z.; Puthuparampil, K. PCT Int. Appl. WO03106413 A 2003; Chem. Abstr. 2003, 140, 59633.
  27. Yamana, K.; Suzuki, N.; Takahama, A. Ine, S. Jpn. KokaiTokkyoKoho JP 179572 2002; Chem. Abstr. 2002, 137, 57555.
  28. Jin, F.; Confalone, P. N. PCT Int. Appl. WO0000481, 2000, 119 pp; Chem. Abstr. 2000, 132, 78560.
  29. Wang, G.; Ella-Menye, J. R.; Sharma, V. Bioorg. Med. Chem. Lett. 2006, 16, 2177-2181.
  30. Wong, G. S. K.; Wu W.; 2-Oxazolines. In The Chemistry of Heterocyclic Compounds; Palmer, D. C.; Ed.,Oxazoles: Synthesis, Reactions, and Spectroscopy, Part B; John Wiley & Sons: Hoboken, NJ, 2004; Vol. 60, pp 331-528.
  31. Campiani, G.; de Angelis, M.; Armaroli, S.; Fattorusso, C.; Catalanotti, B.; Ramunno, A.; Nacci, V.; Novellino, E.; Grewer, C.; Ionescu, D.; et al. J. Med. Chem. 2001, 44, 2507-2510.
  32. Wipf, P.; Miller C. P. J. Am. Chem. Soc. 1992, 114, 10975-10977.
  33. Balazs, A.; Szakonyi, Z.; Fulop F. Synthesis of alicyclic N-substituted 1,3- amino alcohols via 1,3-oxazines. J. Heter. Chem. 2007, 44, 403-406.
  34. Zhao, S. H.; Berger, J.; Clark, R. D.; Sethofer, S. G.; Krauss, N. E.; Brothers, J. M.; Martin, R. S.; Misner, D. L.; Schwab, D.; Alexandrova, L. Bioorg. Med. Chem. Lett. 2007, 17, 3504-3507.
  35. Ali, A.; Sinclair, P. J.; Taylor, G. E. Preparation of 1, 3 - oxazine derivatives as inhibitors of cholesteryl ester transfer proteins. PCT Int. Appl. 2007, 90pp.
  36. Ohno, M.; Tanaka, Y.; Miyamoto, M.; Takeda, T.; Hoshi, K.; Yamada, N.; Ohtake, A. Bioorg. Med. Chem. Lett. 2006, 14, 2005-2021.
  37. Donald, J. R.; Edwards, M. G.; Taylor, R. J. K. Tetrahedron Lett. 2007, 48, 5201-5204.
  38. 38Kurz, T. Tetrahedron 2005, 61, 3091-3096.
  39. 39 Zhao, Z.; O’Brien, J. A.; Lemaire, W.; Williams, J. D. L.; Jacobson, M. A.; Sur, C.; Pettibone, D. J.; Tiller, P. R.; Smith, S.; Hartman, G. D.; et al. Bioorg. Med. Chem. Lett. 2006, 16, 5968-5972.
  40. 40 Brenner, E.; Baldwin, R. M.; Tamagnan, G. Org. Lett. 2005, 7, 937-939.
  41. 41 Dahlgren, A.; Johansson, P.O.; Kvarnstro, I.; Musil, D.; Nilsson, I.; Samuelsson, B. Bioorg. Med. Chem. Lett. 2002, 10, 1829-1839.
  42. 42 Ku, I. W.; Cho S.; Doddareddy, M. R.; Jang, M. S.; Keum, G.; Lee, J.H.; Chung, B. Y.; Kim; Y.; Rhim, H.; Kang, S. B. Bioorg. Med. Chem. Lett. 2006, 16, 5244-5248.
  43. 43Kazmierski, M.; Furfine, E.; Spaltenstein, A.; Wright, L. L. Bioorg. Med. Chem. Lett. 2006, 16, 5226-5230.
  44. 44Shinkre, B. A.; Deshmukh, A. R. Tetrahedron Asymm. 2004, 15, 1081-1084.
  45. 45Pansare, S. V.; Jain, R. P.Org. Lett. 2000, 2, 175-177.
  46. 46 McManus, H. A.; Guiry, P. J. Chem. Rev. 2004, 104, 4151-4202. (b) Ager D. J., Prakash I., Schaad D. R. Chem. Rev. 1996, 96, 835-875.
  47. 47 Abbas, T. R.; Cadogan, J. I. G.; Doyle A. A.; Gosney I.; Hodgson P. K. G.; Howells G. E.; Hulme A. N.; Parsons S.; Sadler, I. H. Tetrahedron Lett. 1997, 38, 4917-4920.
  48. 48 Banks, M. R..; Cadogan, J. I. G.; Gosney, I.; Gould, R. O.; Hodgson, K. G.; McDougall, D. Tetrahedron 1998, 54, 9765-9784.
  49. 49 Meyers, A. I.; Temple, D. L.; Haidukewuch, D.; Mihelich, E. D. J. Org. Chem. 1974, 39, 2787-2793.
  50. 50Jungheim, L. N.; Sigmund, S. K.; Jones, N. D.; Swartzend, J. K. Tet. Lett. 1990, 28, 285.
  51. 51Ordentlich, P., ;Yan, Y.; Zhou, S.; Heyman, R.A. J. Bio. Chem. 2003, 278, 24791-24799.
  52. 52Hoffmann, M.; Chrzanowska, M.; Hermann, T.; Rychlewski, J. J. Med. Chem. 2005, 48, 4482-4486.
  53. 53Knockaert, M.; Gray, N.; Damiens, E.; Chang, Y. T.; Grellier, P.; Grant, K.; Fergusson, D.; Mottram, J.; Soete, M.; Dubremetz, J. F.; et al. Chem. Biol. 2000, 7, 411- 422.
  54. 54 Monaco, E. A.; Beaman-Hall, C. M.; Mathur, A.; Valano, M. L. Biochem. Pharm. 2004, 67, 1947-1964.
  55. 55Langley, B.; D'Annibale, M. A.; Suh, K.; Ayoub, I.; Tolhurst, A.; Bastan, B.; Yang, L.; Ko, B.; Fisher, M.; Beal, S. C; et al. The Journal of Neuroscience, 2008, 28(1), 163-176.
  56. 56 Bach, S.; Knockaert, M.; Reinhardt, J.; Lozach, O.; Schmitt, S.; Baratte, B.; Kokeen, M.; Coburn, S. P.; Tang, L.; Jiang, T.; et al. J. Bio. Chem. 2005, 280, 31208-31219.
  57. 57 Helmut, R. Molbank, 2009, M590, 1-7.
  58. 58George, S.; Kumar, M.; Acharjee, P.; Chakraborty, R.; Ravi, T.K. Acta Pharm. 2008, 58, 119-129.
  59. 59 Zhao, X. L.; Zhao, Y. G.; Guo, S. C.; Song, H. S.; Wang, D. Gong P.Molecules, 2007, 12, 1136-1146.
Publication Details
  Published in : Volume 1 | Issue 1 | March-April 2015
  Date of Publication : 2015-03-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 76-84
Manuscript Number : IJSRST1841247
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Narendra Nirwan, Chandresh Pareek, Anil Chohadia, "Role of Nitrogen-Containing Natural Heterocyclic Compounds in Medical Science : A Mini Review", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 1, Issue 1, pp.76-84, March-April-2015
URL : http://ijsrst.com/IJSRST1841247