Green Chemistry Approaches Towards Synthesis of Various Non-Steroidal Anti - Inflammatory Drugs (Nsaids) Particularly Derivatives of Propanoic Acid, Ethanoic Acid and Fenamic Acid (A Review Article)

Abstract

Green chemistry approaches are the synthetic procedures which have to follow the principles of green chemistry i.e. in case of NSAIDs new leads, particularly novel derivatives of Propanoic acid, Ethanoic Acid and Fenamic Acid will be selected on the basis of virtual screening based on computer aided drug designing and development, followed by their synthesis which should maintain atom economy preferably through multicomponent reaction free from hazardous solvent, should consume less energy i.e. supported by grinding technique, micro-wave or ultrasound irradiation with excellent yield of the product. In short a procedure should be environmentally benign. We wish to present here with a brief review of such procedures for selection of good leads and synthesis of various derivatives of Propanoic acid, Ethanoic Acid and fenamic Acid as (NSAIDs).