A Versatile Approach for Synthesis of Various Pyrimidine Derivatives Clubbed with Pyrazolone Structure and Their Biological Activities

Authors(1) :-Amish P. Khamar

Different pyrimidine derivatives clubbed with pyrazolone structure possessing a diversity of substituents in the 6-position have been synthesized and evaluated for Mycobacterium tuberculosis activities. Several compounds demonstrated IC90 ≤ 10 µg/mL and were found to be active against Mycobacterium tuberculosis strain Compound 8d was found to be most active compound in vitro with IC90 of 1.53.

Authors and Affiliations

Amish P. Khamar
Arts, Science & R. A. Patel Commerce College, Bhadran, Gujarat, India

Pyrazolopyrimidines, Antitubercular Activity, Antimycobacterial Activity, MABA Assay.

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Publication Details

Published in : Volume 3 | Issue 1 | January-February 2017
Date of Publication : 2017-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 658-665
Manuscript Number : IJSRST184134
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Amish P. Khamar, " A Versatile Approach for Synthesis of Various Pyrimidine Derivatives Clubbed with Pyrazolone Structure and Their Biological Activities", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 1, pp.658-665, January-February-2017.
Journal URL : https://ijsrst.com/IJSRST184134
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