An Efficient Approach Towards Synthesis of Pyrimidine Derivatives Bearing Pyridine Nucleus Using L-Proline as a Catalyst

Authors(1) :-Nirul V. Gothi

Pyridine and pyrimidine containing compounds found to possess various biological activities. Biginelli reaction is one of the finest approaches to synthesize pyrimidine derivatives that offer diverse choice of substitutions. This paper describes an efficient approach towards synthesis of pyrimidine derivatives bearing pyridine nucleus using L-proline as a catalyst. Twenty compounds were synthesized in high purity using a simple synthetic program. All the compounds were characterized by NMR, IR and mass spectroscopy.

Authors and Affiliations

Nirul V. Gothi
Arts, Science & R. A. Patel commerce college, Bhadran, Gujarat, India

Pyrimidine, Pyridine, Biginelli reaction, biological activities, NMR, L-proline

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Publication Details

Published in : Volume 3 | Issue 1 | January-February 2017
Date of Publication : 2017-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 674-681
Manuscript Number : IJSRST184136
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Nirul V. Gothi, " An Efficient Approach Towards Synthesis of Pyrimidine Derivatives Bearing Pyridine Nucleus Using L-Proline as a Catalyst", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 3, Issue 1, pp.674-681, January-February-2017.
Journal URL : https://ijsrst.com/IJSRST184136
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