Manuscript Number : IJSRST184136
An Efficient Approach Towards Synthesis of Pyrimidine Derivatives Bearing Pyridine Nucleus Using L-Proline as a Catalyst
Authors(1) :-Nirul V. Gothi Pyridine and pyrimidine containing compounds found to possess various biological activities. Biginelli reaction is one of the finest approaches to synthesize pyrimidine derivatives that offer diverse choice of substitutions. This paper describes an efficient approach towards synthesis of pyrimidine derivatives bearing pyridine nucleus using L-proline as a catalyst. Twenty compounds were synthesized in high purity using a simple synthetic program. All the compounds were characterized by NMR, IR and mass spectroscopy.
Nirul V. Gothi Pyrimidine, Pyridine, Biginelli reaction, biological activities, NMR, L-proline Publication Details
Published in : Volume 3 | Issue 1 | January-February 2017 Article Preview
Arts, Science & R. A. Patel commerce college, Bhadran, Gujarat, India
Date of Publication : 2017-02-28
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 674-681
Manuscript Number : IJSRST184136
Publisher : Technoscience Academy
Journal URL : https://ijsrst.com/IJSRST184136
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