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Copper (0) an Efficient Catalyst for the Synthesis of Biologically Active 1, 2- Amino Alcohols

Authors(6) :-Santosh S. Devkate, Arvind S. Burungale, Ashok S. Pise, Ramesh B. Gawade, Mohan B. Kale2 , Sunil D. Jadhav

The regioselective epoxide ring opening with nucleophiles like amines gives well known 1, 2-difunctionalized amino alcohols. These are present in many natural and synthetic products. The ring opening of epoxide is achieved by cleavage with amine in presence of copper (0) as a catalyst. We have observed that lithium napthalenide reduction of copper (I) produces a highly reactive form of copper (0) that acts as a catalyst for ring opening of epoxides with an amine.
Santosh S. Devkate, Arvind S. Burungale, Ashok S. Pise, Ramesh B. Gawade, Mohan B. Kale2 , Sunil D. Jadhav
Copper (0), Napthalenide, Epoxide, Eugenol, Amino Alcohol, Biological Activity, Spectroscopy.
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Publication Details
  Published in : Volume 4 | Issue 2 | January-February 2018
  Date of Publication : 2018-02-28
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 270-274
Manuscript Number : IJSRST184157
Publisher : Technoscience Academy
PRINT ISSN : 2395-6011
ONLINE ISSN : 2395-602X
Cite This Article :
Santosh S. Devkate, Arvind S. Burungale, Ashok S. Pise, Ramesh B. Gawade, Mohan B. Kale2 , Sunil D. Jadhav, "Copper (0) an Efficient Catalyst for the Synthesis of Biologically Active 1, 2- Amino Alcohols", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 4, Issue 2, pp.270-274, January-February-2018.
Journal URL : http://ijsrst.com/IJSRST184157

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