In-silico molecular characterization of PvDBP involved in malaria

Authors

  • Vinod P. Sinoorkar  PG Department of Bioinformatics, Walchand College of Arts & Science , Solapur, Maharashtra, India
  • Shruti S. Kalashetti  Department of Zoology, Walchand College of Arts & Science ,Solapur, Maharashtra, India
  • Deepali S. Pawar  Department of Zoology, Walchand College of Arts & Science ,Solapur, Maharashtra, India

Keywords:

Plasmodium vivax, invasion, reticulocyte, Duffy binding protein, drug designing.

Abstract

Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. India recorded 6% of the world’s new malaria cases in 2016 which stood at 216 million according to the World Malaria report 2017 by World Health Organization (WHO). India witnessed a total of 331 malaria death in 2016 making it the highest in the entire Southeast Asia region. The two major human malaria parasite species in India are Plasmodium falciparum and P. vivax, P. malarie has been reported in the eastern India. Understanding the pathogenesis of malaria requires investigation of mechanisms including parasite invasion, parasite biology and host defence. The parasite life cycle illustrates the interplay of parasite and host interactions. It is during the blood-stage of infection that malaria disease occurs and host immune responses to merozoite surface antigens and targeting merozoite surface proteins and invasion ligands have been important areas of research. P. vivax has a very strong preference for invasion of reticulocytes and is largely restricted to invading young reticulocytes that still bear CD71. Plasmodium vivax requires interaction with the Duffy antigen receptor for chemokines (DARC) to enable its invasion of human erythrocytes. Interaction with DARC is mediated by the P. vivax Duffy-binding protein (PvDBP) and is essential for junction formation, which is a key step in the invasion process. Hence our present study mainly focuses to unfold the molecular mechanism of PvDBP in invasion process by detailed understanding of its molecular features viz retrieving of protein sequence information, analysis of physicochemical properties, secondary structural elements, prediction of tertiary structure, analysis of binding domains and residues using various bioinformatics tools and softwares. Thorough understanding of molecular structure and function of PvDBP can put insights into its key role in invasion process and can serve as major protein target for structure based drug designing against malaria.

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International Journal of Scientific Research in Science and Technology

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Published

2018-04-30

Issue

Volume 4, Issue 5, March-April-2018

Section

Research Articles

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How to Cite

[1]
Vinod P. Sinoorkar, Shruti S. Kalashetti, Deepali S. Pawar, " In-silico molecular characterization of PvDBP involved in malaria, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 5, pp.444-450, March-April-2018.