Antitubercular and Molecular Docking Studies of Some 5 - Arylmethylene – Pyrimidine-2, 4, 6-Triones

Authors

  • GajananHegde  Department of Chemistry, Gokhale Centenary College, Ankhola, Karnataka, India
  • Bharath Raj B  Karnataka Veterinary,Animal and Fisheries Sciences University, Bidar, Karnataka, India

Keywords:

5-arylmethylene-pyrimidine-2,4,6-triones, aromatic aldehydes, barbituric acid, antituberculosis activity , Molecular docking studies

Abstract

A series of 5-arylmethylene-pyrimidine -2, 4, 6-triones (3a-3j) were synthesized by condensation of aromatic aldehydes (1) and barbituric acid (2) in aqueous medium in presence of Amberlite IR-120 H catalyst. The structures of the synthesized compounds were confirmed by FT-IR, 1H NMR and mass spectroscopic studies. All the synthesized compounds were subjected to anti-tuberculosis screening and molecular docking studies. Among them 3a and 3i were found to possess broad-spectrum antituberculosis activity and all the synthesized compounds are found to be promising potential specific inhibitors under molecular docking studies.

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International Journal of Scientific Research in Science and Technology

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Published

2018-04-30

Issue

Volume 4, Issue 5, March-April-2018

Section

Research Articles

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How to Cite

[1]
GajananHegde, Bharath Raj B, " Antitubercular and Molecular Docking Studies of Some 5 - Arylmethylene – Pyrimidine-2, 4, 6-Triones , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 5, pp.622-627, March-April-2018.