Anti-Inflammatory Activity of Alkaloids From Murraya Koenigii Leaves In Animal Models

Authors

  • Rupali Patil  Department of Pharmacology, Gokhale Education Society’s Sir Dr. M. S. Gosavi College of Pharmaceutical Education & Research, Nasik, India

Keywords:

Inflammation, Carbazole Alkaloid, Carageenan, Murraya Koenigii

Abstract

Alkaloids have a wide range of pharmacological properties, including anti-inflammatory activity. The purpose of the present study was to investigate the anti-inflammatory and antioxidant activity of Murraya koenigii leaves. The hind paw edema was produced in rats by subplantar injection of Carageenan. Pet ether extract (PMK) of Murraya koenigii leaves and alkaloids (AMK) isolated from PMK at doses of 100 and 300 mg/kg/day, p.o. were given for 11days to observe % inhibition of paw edema which was comparable with Aspirin (100 mg/kg, p.o.) used as a reference drug. PMK and AMK produced a significant (p<0.05) inhibition of paw edema. PMK and AMK treatment significantly reversed the Carageenan induced decrease in paw Superoxide dismutase (SOD), Catalase (CAT), reduced glutathione (GSH) levels as compared to Carageenan treated rats. Lipid peroxidation (LPO) induced by Carageenan treatment was significantly reversed after administration of PMK and AMK. hematological analysis of carageenan-treated rats exhibited significant (p<0.05) decrease in RBC count, Hb content and PCV after treatment with aspirin, compared to the control. PMK or AMK treated animals showed normal erythrocyte (RBC) count, hemoglobin (Hb), packed cell volume (PCV), near to control group. The total leukocyte (WBC), lymphocyte, neutrophils, and basophils count were higher in rats treated with aspirin compared to control. PMK and AMK treatment showed decreased platelet count compared to control. The significant reductions observed in the activity of ALT and AST in PMK and AMK treated animals compared to control.

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International Journal of Scientific Research in Science and Technology

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Published

2018-06-30

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Volume 4, Issue 8, May-June-2018

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Research Articles

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[1]
Rupali Patil, " Anti-Inflammatory Activity of Alkaloids From Murraya Koenigii Leaves In Animal Models, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 4, Issue 8, pp.635-644, May-June-2018.