Synthesis, Characterization & Antimicrobial Activity of Some New Dihydropyridine Derivatives Derived From 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide

Authors

  • D. N. Joshi  Department of Chemistry, R. R. Mehta college of Science & C.L.Parikh College of Commerce Palanpur, Gujarat, India

Keywords:

3-Aryl-2-isobutanoyl-N-phenyl-acrylamide, Pyrazoles, Antimicrobial activities.

Abstract

1,4-Dihydropyridine is the significant subclass of pyridines, the best known heterocyclic compounds which are associated with good number of pharmacological activities. 1,4-Dihydropyridines whether symmetrical or asymmetrical are expected for their cardiovascular and other pharmacological properties. Some new 4-Aryl-2,6-diisopropyl-3,5-bis[N-phenyl-aminocarbonyl]-1,4-dihydropyridines.The Dihydropyridine derivatives of Type (1a-j) have been synthesized by the condensation of 3- Aryl-2-isobutanoyl-N-phenyl-acrylamide and 4-Methyl-3-oxo-N-phenyl-pentanamide and ammonia. All the prepared compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities

References

  1. Godfraind T., Miller R. & Wibo M.; Pharmacol. Rev., 38, 321 (1986).
  2. Janis R. A., Silver P. J., Triggle D.; J. Adv. Drug Res., 16, 309 (1987).
  3. Sausins A. & Duburs G.;Heterocycles, 27, 269 (1988).
  4. Mager P. P., Coburn R. A., Sol. A. J., Triggle D. J. & Rothe H.;Drug Discovery 8, 273(1992).
  5. Mannhold R., Jablonka B., Voigdt W., Schoenafinger K. & Schraven E.; J. Med.Chem., 27, 229 (1992).
  6. Gaudio A. C., Korolkovas A. & Takahata Y.;J. Pharm. Sci., 83, 1110 (1994).
  7. Alker D., Arrowsmith J. E., Cambell S. E. & Cross, P. E.; Eur. J. Med. Chem.,26 (9), 907 (1991).
  8. Cupka P.;Czech. CS 243, 591 (1987); Chem. Abstr. 110, 8051 (1989).
  9. Singer T. P. & Kearney E. B.; Advan. Enzymol., 15, 79 (1954).
  10. Kaplan N. O.; Rex. Chem. Progr., 16, 177 (1955).
  11. Westhiemer F. H.; Advan. Enzymol., 24, 469 (1962).
  12. Sund H., Diekmann K. & Wallenfels K.; Advan. Enzymol., 26, 115 (1964).
  13. Colowick S. P., Van Eys J. & Park J. H.; Compr. Biochem., 14, 1 (1966).
  14. Chaykin S.; Ann. Rev. Biochem., 36, 149 (1967).
  15. Therapeutic guidelines, cardiovascular, 3rd ed. Victoria:Therapeutic Guidelines; (1998).
  16. Calcium channel blocking agents in USP DI. 22nd ed.:Micromedex; . 42, 727 (2002).
  17. A. L. Barry; The antimicrobial susceptibility test: Principle and practices, edited by llluslea & Febiger , (Philadelphia), USA, 180; Biol. Abstr., 1977, 64, 25183
  18. Panda J. Srinivas S. V., Rao M. E.; J. Indian Chem. Soc., 79(9), 770-1 (2002); Chem. Abstr., 138, 153499n (2003).

International Journal of Scientific Research in Science and Technology

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Published

2015-07-30

Issue

Volume 1, Issue 3, July-August-2015

Section

Research Articles

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How to Cite

[1]
D. N. Joshi, " Synthesis, Characterization & Antimicrobial Activity of Some New Dihydropyridine Derivatives Derived From 3-Aryl-2-Isobutanoyl-N-Phenyl-Acrylamide , International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 1, Issue 3, pp.192-195, July-August-2015.